초기 성 학대 경험이 있는 여성 공황장애 환자의 임상적 특성 = Clinical Characteristics of Female Panic Disorder with Early Sexual Abuse History

다국어 초록 (Multilingual Abstract)

Objectives The objective of this study is to investigate differences of clinical characteristics between a healthy female control group and female panic disorder (PD) patients with early sexual abuse history (PD+S) and without early sexual abuse history (PD-S). Methods We examined data from 83 patients diagnosed with PD and 20 healthy control subjects. We divided the patients with PD into PD+S (32 patients) and PD-S (51 patients) to compare demographic and clinical characteristics. The following instruments were applied: the Stress coping strategies, the Beck Depression Inventory (BDI), the Panic Disorder Severity Scale, the Anxiety Sensitivity Index-Revised (ASI-R), the Albany Panic and Phobia Questionnaire (APPQ) and the NEO-neuroticism. Results Compared to the PD-S, the PD+S group showed higher scores in neuroticism and the APPQ. And, in the PD+S group, the scores of neuroticism were correlated with the ASI-R and APPQ subscale scores and the APPQ total scores were associated with the scores of BDI. Conclusions This study shows that female PD+S patients have higher scores in neuroticism and the APPQ than the PD-S group, and these factors are associated with the panic-related symptoms severity. It emphasizes the need of specific strategies considering the childhood abuse history such as early sexual abuse in clinical approach among patients with PD.

참고문헌 (Reference)

1 김용구, "주요우울증에서 스트레스, 염증반응, 신경조직발생" 대한생물정신의학회 18 (18): 169-175, 2011

2 Gunthert KC, "The role of neuroticism in daily stress and coping" 77 : 1087-1100, 1999

3 Schmidt NB, "The role of anxiety sensitivity in the pathogenesis of panic: prospective evaluation of spontaneous panic attacks during acute stress" 106 : 355-364, 1997

4 Tekin A, "The relationship between childhood sexual/physical abuse and sexual dysfunction in patients with social anxiety disorder" 70 : 88-92, 2016

5 Flint J, "The genetic basis of neuroticism" 28 : 307-316, 2004

6 Ju-Ri Jeon, "The Early Trauma Inventory Self Report-Short Form: Psychometric Properties of the Korean Version" 대한신경정신의학회 9 (9): 229-235, 2012

7 Jacobs N, "Stressrelated negative affectivity and genetically altered serotonin transporter function: evidence of synergism in shaping risk of depression" 63 : 989-996, 2006

8 Lazarus RS, "Stress, appraisal, and coping" Springer Publishing Company 1984

9 Cox BJ, "Situations and specific coping strategies associated with clinical and nonclinical panic attacks" 30 : 67-69, 1992

10 Lahey BB, "Public health significance of neuroticism" 64 : 241-256, 2009

11 Stough C, "Psychophysiological correlates of the NEO PI-R openness, agreeableness and conscientiousness:preliminary results" 41 : 87-91, 2001

12 Schmidt NB, "Prospective evaluation of the etiology of anxiety sensitivity: test of a scar model" 38 : 1083-1095, 2000

13 Watt MC, "Overcoming the Fear of Fear: How to Reduce Anxiety Sensitivity" New Harbinger Publications 2008

14 DeYoung CG, "Moderation of the association between childhood maltreatment and neuroticism by the corticotropin-releasing hormone receptor 1 gene" 52 : 898-906, 2011

15 Walker EA, "Medical and psychiatric symptoms in women with childhood sexual abuse" 54 : 658-664, 1992

16 Roy-Byrne PP, "Lifetime panic-depression comorbidity in the National Comorbidity Survey. Association with symptoms, impairment, course and help-seeking" 176 : 229-235, 2000

17 Wosu AC, "History of childhood sexual abuse and risk of prenatal and postpartum depression or depressive symptoms: an epidemiologic review" 18 : 659-671, 2015

18 Safren SA, "History of childhood abuse in panic disorder, social phobia, and generalized anxiety disorder" 190 : 453-456, 2002

19 Aleksandrova LR, "Genetic underpinnings of neuroticism: a replication study" 3 : 119-, 2012

20 Dinwiddie S, "Early sexual abuse and lifetime psychopathology:a co-twin-control study" 30 : 41-52, 2000

21 Folkman S, "Coping: pitfalls and promise" 55 : 745-774, 2004

22 Stanton AL, "Coping through emotional approach: scale construction and validation" 78 : 1150-1169, 2000

23 Ozkan M, "Comorbid personality disorders in subjects with panic disorder: do personality disorders increase clinical severity?" 46 : 20-26, 2005

24 Roy A, "Childhood trauma and neuroticism as an adult: possible implication for the development of the common psychiatric disorders and suicidal behaviour" 32 : 1471-1474, 2002

25 Weiss EL, "Childhood sexual abuse as a risk factor for depression in women: psychosocial and neurobiological correlates" 156 : 816-828, 1999

26 Goodwin RD, "Childhood abuse and familial violence and the risk of panic attacks and panic disorder in young adulthood" 35 : 881-890, 2005

27 Wellman MM, "Child sexual abuse and gender differences: attitudes and prevalence" 17 : 539-547, 1993

28 Garnefski N, "Child sexual abuse and emotional and behavioral problems in adolescence: Gender differences" 36 : 323-329, 1997

29 Ceslowitz SB, "Burnout and coping strategies among hospital staff nurses" 14 : 553-558, 1989

30 Nelson EC, "Association between self-reported childhood sexual abuse and adverse psychosocial outcomes: results from a twin study" 59 : 139-145, 2002

31 Walsh K, "Adult coping with childhood sexual abuse: a theoretical and empirical review" 15 : 1-13, 2010

32 Fawzy FI, "A structured psychiatric intervention for cancer patients. II. Changes over time in immunological measures" 47 : 729-735, 1990

33 Beitchman JH, "A review of the long-term effects of child sexual abuse" 16 : 101-118, 1992

34 Brown TA, "A psychometric reanalysis of the Albany Panic and Phobia Questionnaire" 43 : 337-355, 2005