표고버섯이 고지방식이로 유도한 비만 흰쥐에 미치는 항비만 효과

국문 초록 (Abstract)

본 연구는 표고버섯 물추출물의 항비만 효과를 알아보기 위하여 6주령의 수컷 C57BL/6 마우스를 이용하여 고지방식이와 함께 표고버섯 물추출 분말을 1%, 3%, 5% 수준으로 첨가하여 12주간 공급하였다. 고지방 식이섭취는 체중, 혈청지질 농도 및 지방조직 무게를 증가시켰다. 표고버섯 물추출물 섭취는 고지방식이로 증가된 혈청 총콜레스테롤, 중성지방, LDL-콜레스테롤 농도를 현저히 감소시켜 대조군보다 더 낮은 값을 나타냈다. 또한 5% 표고버섯 물추출물 첨가군은 고지방 식이군보다 체중 및 피하지방량이 현저히 감소하였다. 변배설량은 3%와 5% 표고버섯 물추출물 첨가군에서 고지방 식이군보다 현저히 증가하였다. 표고버섯 물추출물 섭취는 고지방식이로 인해 증가된 간조직의 지방축적과 지질과산화물 형성을 억제하였으며, 특히 5% 표고버섯 물추출물 섭취군에서 지질과산화물 형성이 유의적으로 감소되었고 총 항산화 활성도 유의적으로 가장 높게 나타났다. 고지방식이군은 간조직의 조직염색에서 지방간이 심하게 진행된 것이 발견되었고, 표고버섯 물추출물 섭취군은 지방세포에 지방이 침투하지 않은 간지방증 소견을 보였다. 위의 결과를 통하여 볼 때 표고버섯은 체중 및 체지방 감소, 그리고 혈청지방 농도 개선에 효과가 있어 비만관리에 도움을 주는 것으로 사료된다.

다국어 초록 (Multilingual Abstract)

The aim of this study was to investigate the anti-obesity effects of Lentinus edodes water extract powder (LEP) in mice fed a high fat diet (HF, 45% kcal fat). Mice were administrated a HF diet supplemented with 1%, 3%, or 5% LEP for 12 weeks. Consumption of HF diet caused increases in body weight, serum lipid profiles, and adipose tissue weights. Serum TC and TG levels in the LEP-supplemented groups were lower than those in the NC group. Supplementation with 5% LEP significantly suppressed body weight gain and reduced the weight of subcutaneous adipose tissue compared to the HF group. HF diet ingestion resulted in higher lipid content and increased lipid peroxidation in the liver. However, LEP supplementation inhibited accumulation of hepatic lipids induced by HF diet, considerably decreased MDA levels, and elevated total antioxidant activity in the livers of mice in the 5% LEP group. Histopathological analysis indicated that the livers of mice fed HF diet developed hepatic steatosis, whereas LEP-treated groups showed small fat droplets. These results suggest that long-term supplementation with LEP may also have an ameliorating effect on HF-induced obesity.

목차 (Table of Contents)

• ABSTRACT
• 서론
• 재료 및 방법
• 결과 및 고찰
• 요약
• REFERENCES

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