Evaluation of Cardiac Functions in Children and Adolescents with Type 1 Diabetes|RISS 상세보기

다국어 초록 (Multilingual Abstract)

Background: Cardiac dysfunction in patients with type 1 diabetes (T1D) represents one of the serious complications. To evaluatethe cardiac function in children with T1D by conventional echocardiography and tissue Doppler imaging (TDI).
Methods: The study included 40 T1D patients (age between 6 and 16 years) with > 5 years duration of diabetes and 42 healthycontrol children. The patients were subjected to clinical evaluation and laboratory investigations [glycosylated hemoglobin A1c(HbA1c), serum lipids and lipoproteins]. Conventional echocardiography and TDI were performed to patients and controls.
Results: The patients had lower early diastolic filling velocity (E wave) of the tricuspid valve and mitral valves with a p valueof (0.000 and 0.006, respectively). TDI revealed that patients had lower S’velocity of the T1D, shorter isovolumic contractiontime, longer isovolumic relaxation time and lower E/E’ of the right ventricle than controls (p value 0.002, 0.001, 0.004, 0.003,and 0.016, respectively). The left ventricle (LV)-T1D of the patients was significantly higher (p value 0.02). Twenty eight patientshad poor glycemic control without significant differences between them and those with good glycemic control regarding echocardiographicdata. Patients with dyslipidemia (13 patients) had higher late diastolic filling velocity of the mitral valve (A) and thelower LV late tissue velocity (A’) (p wave 0.047 and 0.015). No correlation existed between the duration of illness or the level ofHbA1c and the echocardiographic parameters.
Conclusion: Diabetic children have evidence of echocardiographic diastolic dysfunctions. Periodic cardiac evaluation withboth conventional and tissue Doppler echocardiography is recommended for early detection of this dysfunction.

번역하기

참고문헌 (Reference)

1 Gul K, "Tissue Doppler imaging must be performed to detect early left ventricular dysfunction in patients with type 1 diabetes mellitus" 10 : 841-846, 2009

2 Yu CM, "Tissue Doppler imaging a new prognosticator for cardiovascular diseases" 49 : 1903-1914, 2007

3 American Diabetes Association, "Standards of medical care in diabetes-- 2012" 35 (35): S11-S63, 2012

4 Gökşen D, "Serum adiponectin and hsCRP levels and non-invasive radiological methods in the early diagnosis of cardiovascular system complications in children and adolescents with type 1 diabetes mellitus" 5 : 174-181, 2013

5 Fang ZY, "Relationship between longitudinal and radial contractility in subclinical diabetic heart disease" 106 : 53-60, 2004

6 Nagueh SF, "Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging" 17 : 1321-1360, 2016

7 Nagueh SF, "Recommendations for the evaluation of left ventricular diastolic function by echocardiography" 10 : 165-193, 2009

8 Kwiterovich PO Jr, "Recognition and management of dyslipidemia in children and adolescents" 93 : 4200-4209, 2008

9 Marcovecchio ML, "Prevalence of abnormal lipid profiles and the relationship with the development of microalbuminuria in adolescents with type 1 diabetes" 32 : 658-663, 2009

10 Rubler S, "New type of cardiomyopathy associated with diabetic glomerulosclerosis" 30 : 595-602, 1972