Tumor Necrosis Factor 유전자 다형성을 이용한한국인 알레르기비염환자에서의 감수성에 대한 연구 = A Study of Susceptibility between Allergic Rhinitis andTumor Necrosis Factor Gene Polymorphism Study in Korean

다국어 초록 (Multilingual Abstract)

Background and Objectives：Tumor necrosis factor-α (TNF-α) is recognized as a proinflammatory host alert cytokine that is synthesized early during inflammation, and elevations of this cytokine have been reported in patients with allergic rhinitis. The TNF-α gene is located on chromosome 6p within the class III region of the major histocompatibility complex. The most widely studied polymorphism within the TNF-α gene involves a guanine (G)/adenine (A) substitution at position -308. We therefore tested whether TNF-α -308G/A polymorphism are associated with allergic rhinitis in a Korean population. Subjects and Method：Blood samples for genetic analysis were obtained from 191 individuals with allergic rhinitis and from 192 healthy subjects without atopic diseases. Polymerase chain reaction-based assay for TNF-α -308G/A was used for genotyping. Serum total IgE levels were determined by using the immunoassay. Eosinophil values were determined by eosinophil numbers per total cell numbers per μl. Results：There were no differences in the frequencies of the genotypes and alleles of TNF-α -308G/A in the controls and patients(p>0.05). Blood eosinophil count and total serum IgE levels were not statistically different in the genotypes of TNF-α -308G/A in allergic rhinitis(p>0.05). Conclusion：We thought that the TNF-α -308G/A polymorphism is unlikely to be an important marker for predisposition to allergic rhinitis. A further study involving a larger Korean population might be in need.

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