미생물 유래 styrene monooxygenase를 이용한 광학활성 styrene oxide 유도체의 비대칭합성

국문 초록 (Abstract)

광학활성 styrene oxide는 친전자성반응, 친핵성반응, 산 ? 염기반응, 산화?환원반응 등 다양한 반응을 유도할 수 있어 광학활성 중간체로 널리 사용될 수 있다. Styrene monooxygenase (SMO)를 생촉매로 이용하여 styrene의 side-chain 이중결합에 입체선택적으로 에폭사이드 링을 도입시켜 광학활성 styrene oxide 유도체를 제조할 수 있다. 다양한 기질 특이성을 가진 신규 SMO 생촉매 개발, 이상계 반응 시스템, in situ 분리 공정, multimeric oxygenase 효소 발현 및 안정화 기술 개발, NADH 등 cofactor regeneration 등에 대한 연구개발이 활발히 진행되고 있어, 미생물 유래의 SMO를 생촉매로 활용하는 광학활성 styrene oxide 유도체 제조 기술의 상업화가 기대된다.

다국어 초록 (Multilingual Abstract)

Enantiopure styrene oxide derivatives are versatile building blocks for the synthesis of enantiopure pharmaceuticals. Styrene monooxygenase (SMO) catalyzes an asymmetric addition of an oxygen atom into a double bond of vinylaromatic compounds. SMO is a commercially potential biocatalyst to synthesize a variety of enantiopure epoxides with high enantiopurity and recovery yield. In this paper, development of SMO biocatalyst and commercial feasibility of SMO-catalyzed asymmetric synthesis of enantiopure styrene oxide derivatives are reviewed.

목차 (Table of Contents)

• Abstract
• 서론
• 본론
• 전망 및 결론
• 요약
• REFERENCES

참고문헌 (Reference)

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