Two different hollow porous inorganic polymers, SiO2 nanoparticle and TiO2 nanoparticle were produced to examine their possibility as delivery systems of two peptide drugs, glucagon-like peptide-1 (Glp-1) and enfuvirtide (ENF) in this work. Specifical...
Two different hollow porous inorganic polymers, SiO2 nanoparticle and TiO2 nanoparticle were produced to examine their possibility as delivery systems of two peptide drugs, glucagon-like peptide-1 (Glp-1) and enfuvirtide (ENF) in this work. Specifically, their encapsulation in hollow porous silica nanoparticles (HPSNs) and their release from HPSNs were investigated. HPSNs are capable of loading Glp-1 and ENF and they are released from HPSNs by roughly 10%. Our results represent that HPSNs are promising candidates for preservation of Glp-1 and ENF from biodegradability and for their longtime release. And how much hollow porous nanoparticles (HPNs) affect the hair growth of minoxidil was also investigated. It appears that both HPSNs and hollow porous TiO2 nanoparticles enhance the hair growth effect of minoxidil.