저분자량 수용성 키토산을 이용하여 제조된 Microspheres 의 생분해성 = Biodegradability of Microspheres Prepared using Low Molecular Water Soluble Chitosan

다국어 초록 (Multilingual Abstract)

This study introduced the novel colon targeting drug delivery system as preparing the microspheres loaded drug using low molecular water soluble chitosan(LMWSC). This LMWSC microspheres are a suitable device for pharmaceutical application because of theirs biodegradable, biocompatibility, and mucoadhesive characteristics. The LMWSC was prepared by acid decomposition with high molecular insoluble chitosan. And then the WSC microspheres were prepared by crosslinking agent, glutaradehyde, chitosan aqueous in liquid paraffin oil contained emulsifier, span80. The morphology of the LMWSG microspheres which were prepared according to amounts of cross-linking agent was observed by a scanning electron microscopy(SEM). This LMWSC microspheres were prepared by loading drug, Norfloxacin(NFx). In vitro, the biodegradable experiment was carried out in phosphate buffered saline(PBS, 0.1M, pH 7.4) at 37±0.5℃. It was observed that the biodegradability was influenced by amounts of cross-linking agent.