Background: Aurora kinase A (Aurora-A) plays an important role in regulation of mitosis and cytokinesis. Dysregulated Aurora-A leads to mitotic faults and results in pathological conditions. No studies on Aurora-A expression in human diabetic skin tis...
Background: Aurora kinase A (Aurora-A) plays an important role in regulation of mitosis and cytokinesis. Dysregulated Aurora-A leads to mitotic faults and results in pathological conditions. No studies on Aurora-A expression in human diabetic skin tissue have been reported. In light of this, we explored the expression of Aurora-A in human diabetic skin tissue. Methods: Aurora-A protein was evaluated by western blotting in 6 human diabetic skin tissue and 6 normal skin specimens. Results: Increased expression of Aurora-A protein was detected in all diabetic skin tissues both in western blot analysis and immunohistochemical staining. However, in normal skin tissues, there were no bands of Aurora-A protein in western blotting and also negative in immunohistochemical staining. Conclusion: There have been no studies on the expression of Aurora-A in diabetic skin tissues so far. We thought that oxidative DNA damage related to the expression of Aurora-A protein and Aurora-A could be involved in human diabetic skin tissue.