흰쥐 뇌에서의 L형 및 P형 칼슘 채널 mRNA의 분포에 관한 연구 = Localization of L-type and P-type Voltage Dependent Calcium Channel α1 Subunit mRNA in the Rat Brain

다국어 초록 (Multilingual Abstract)

Voltage-dependent calcium channels present in vertebrate cells play important roles in excitation-contraction coupling mechanisms and signal transduction. These channels are classsified into L, N, P and T-types, based on their electrophysiologic and pharmacologic properties.
The localization of α1 subunits of L-type and P-type calcium channels in adult rat brain and 19 days old rat embryo were analyzed by in situ hybridization histochemistry. The mRNA for the P-type voltage dependent calcium channel α1 subunit was prominently localized in Purkinje cell layer of cerebellum, CA3 regions of hippocampus and inferior colliculus. In the 19 days old embryo. L-type channel expressed not only in the nervous system but also in the nonneuronal tissues but P-type channel was exclusively localized in the neuronal tissues.
Thus, regional distribution of L-and P-type calcium channel mRNA in rat brain suggests that these types of calcium channels may play an important role in excitation-secretion coupling functions in the neuroendocrine system and in inducing long-term depression in the cerebellar cortex, respectively.