신원방우황청심원액의 심혈관계에 관한 약효 = Pharmacological Actions of New Wonbang Woohwangchungsimwon Liquid on Cardiovascular System

다국어 초록 (Multilingual Abstract)

Abstract-In order to investigate the pharmacological properties of New Wonbang Woohwangchungsimwon Liquid (NSCL), effects of Wonbang Woohwangchungsimwon Liquid (SCL) and NSCL were compared. In isolated rat aorta, NSCL and SCL showed the relaxation of blood vessels in maximum contractile response to phenylephrine (10^-6 M) regardless to intact endothelium or denuded rings of the rat aorta. Furthermore, the presences of the inhibitor of NO synthase and guanylate cyclase did not affect the relaxing effect of NSCL and SCL. NSCL and SCL inhibited the vascular contractions induced by acetylcholine, prostaglandin endoperoxide or peroxide in a dose-dependent manner. In conscious spontaneously hypertensive rats (SHRs), NSCL and SCL significantly decreased heart rate. NSCL and SCL, at high doses, had a negative inotropic effect that was a decrease of left ventricular developed pressure and (-dp/dt)/(+dp/dt) in the isolated perfused rat hearts, and also decreased the contractile force and heart rate in the isolated rat right atria. In excised guinea-pig papillary muscle, NSCL and SCL had no effects on parameters of action potential such as resting membrane potential, action potential amplitude, APD_90 and V_max at low doses, whereas inhibited the cardiac contractility at high doses. These results suggested that NSCL and SCL have weak cardiovascular effects with relaxation of blood vessels and decrease of heart rate, and that this effect is no significant differences between cardiovascular effects of two preparations.

목차 (Table of Contents)

• 실험방법
• 실험동물
• 사용시료 및 시약
• 실험방법
• 흰쥐 흉부 대동맥에서의 이완반응
• 선천성 고혈압 쥐의 대동맥에서 endothelium-derived contracting factor(EDCF) 의한 혈관수축에 미치는 영향
• 선천성 고혈압 쥐의 혈압과 심박동수에 미치는 영향
• 심근 수축력과 심혈류량에 대한 영향
• 적출 유두근의 활동전위에 미치는 영향
• 심계장진에 대한 효과
• 통계처리
• 실험결과
• 흰쥐 흉부 대동맥에서의 이완반응
• 선천성 고혈압 쥐의 대동맥에서 endothelium-derived contracting factor(EDCF)에 의한 혈관수축에 미치는 영향
• 선천성 고혈압 쥐의 혈압 및 심박동수에 미치는 영향
• 심장기능에 대한 영향
• 적출우심방의 심박수 및 수축력에 미치는 영향
• 적출 유두근의 활동전위에 미치는 영향
• 심계항진에 대한 효과
• 고찰
• 감사의 말씀