Melatonin이 수면에 미치는 영향 = The Effects of Melatonin on Sleep

다국어 초록 (Multilingual Abstract)

OBJECTIVES : Author tried to evaluate the hypnotic effect of melatonin and melatonin induced daytime sleepiness and to identify the cumulative effect of short-term administration of melatonin for 3 successive days, and remaining effect after discontinuation. INTERVENTION : Subjects visited our laboratory by 08:00 at the first day, and they had baseline MSLT (from 10:00 to 22:00 at 2 hours' interval) while they had 7 naps during the day. Each time, the subjects completed SSS and RT before they underwent an MSLT to evaluate their sleepiness and to evaluate their performance. Next day, 6mg of melatonin was administered to healthy young males at 09:00 hour, and the concurrent effects on sleep latency, daytime sleepiness and reaction time were recorded. PARTICIPANTS : Sixteen healthy, normal young male college students participated in this study. Participating subjects were in good physical and psychological health and were asymptomatic as to sleep/wake complaintsRESULT : The result were summarized as follows.1. As compared to baseline, the hypnotic effect of melatonin appeared within 1 hour, and the effect continued over 7 hours. Sleep latency was normal range on the day of discontinuation. 2. Subjects had significantly more subjective daytime sleepiness after melatonin administration. Melatonin induced daytime sleepiness appeared within 3 hour after adminisration, and the condition continued over 7 hours.3. Compared to baselines, there was no effect on reaction time.4. The longer the reaction time of second drug administration day, the longer the reaction time of third drug administration day.