Guanethidine이 백서 피부판에 미치는 효과에 대한 실험적 연구 = THE EFFECT OF GUANETHIDINE ON FLAP SURVIVAL IN RATS

다국어 초록 (Multilingual Abstract)

Flap survival is still a major problem in reconstructive surgery.
To increase flap survival, thematters that must be considered are the size and location of the flap that can be supported by the available blood supply, delaying the flap to increase its blood supply, and maintaining the blood supply present in the flap. The term delaying a flap is frequently used in the field of reconstructive surgery to indicate tnat the flap is being developed and transferred in more than a single stage to ensure its safety. There are various methods in delaying flap; surgical delay, pharmacological delay and electrical delay.
After Bier(1908), Hannington- Kiff(1974) produced an effective sympathetic blockade with guanethidine in the upper and lower extremities of patient. Finseth(1978) described the prevention of skin flap necrosis by a course of treatment with vasodilating drugs.
Arts (1980) reported extremely increased flap survival in rabbit ear by regional sympathetic blockade with guanethidine. Aim of this study is to clarify the effectiveness of the pharmacological dealy by using the guanethidine which is a sympathetic ganglionic blocking agent.
The experiments were carried out to confirm that whether the guanethidine could prevent flap necrosis in neurovascular island flaps and random pattern flaps in rats, and also the effectiveness of the drug could be different by way of administration.
The results demonstrated that the rats which were pretreated with guanethidine systemically showed significant improvement in the survival of neurovascular island flap, but there were little improvment in the survival of random pattern flap. However, when the rats were treated with guanethidine locally for 10 minutes before the flaps were raised there was no improvement in flap survival.
In conclusion, when the guanethidine was administered systemically, there was significant pharmacological delay effect on neurovasuclar island flaps, but no effect on random pattarn flaps. When the guanethidine was administered locally, there was no pharmacological delay effect on either pattern flaps