Hepatoprotective and free radical scavenging activities of Lagerstroemia speciosa Linn. leaf extract

다국어 초록 (Multilingual Abstract)

The presrent study deals with the amelioration by Lagerstroemia speciosa Linn. leaf extract against
hepatotoxicity induced by carbon tetrachloride (CCl4), which was evaluated in terms of serum
marker enzymes like serum glutamate pyruvate transaminase, serum glutamate oxaloacetate
transaminase, alkaline phosphatase, serum total bilirubin, total protein levels along with
concomitant hepatic and antioxidants like superoxide dismutase, catalase, glutathione, glutathione
peroxidase and lipid peroxidation enzymes were monitored. These biochemical parameters
altered by the single dose level of CCl4 (0.75 ml/kg body weight, i.p). Pre treatment with L. speciosa prior
to the administration of CCl4, at the doses of 50 and 250 mg/kg. body weight/day, p.o. for 7 days,
significantly restored all the serum and liver tissue parameters near to the normal levels,
respectively. Silymarin was used as a reference standard, prior to the administration of CCl4 to
rats. These findings indicate the protective potential of L. speciosa against hepato toxicity which
possibly involve mechanism related to its ability of selective inhibitors of (reactive oxygen species
like antioxidants brought about significant inhibition of TBARS suggesting possible involvement
of O2· -, HO2· , and ·OH. In conclusion, the amelioration may be attributed to the synergistic effects
of its constituents rather than to any single factor as the leaves are rich in tannins, sterols,
flavonoids, saponins etc.

다국어 초록 (Multilingual Abstract)

The presrent study deals with the amelioration by Lagerstroemia speciosa Linn. leaf extract against
hepatotoxicity induced by carbon tetrachloride (CCl4), which was evaluated in terms of serum
marker enzymes like serum glutamate pyruvate transaminase, serum glutamate oxaloacetate
transaminase, alkaline phosphatase, serum total bilirubin, total protein levels along with
concomitant hepatic and antioxidants like superoxide dismutase, catalase, glutathione, glutathione
peroxidase and lipid peroxidation enzymes were monitored. These biochemical parameters
altered by the single dose level of CCl4 (0.75 ml/kg body weight, i.p). Pre treatment with L. speciosa prior
to the administration of CCl4, at the doses of 50 and 250 mg/kg. body weight/day, p.o. for 7 days,
significantly restored all the serum and liver tissue parameters near to the normal levels,
respectively. Silymarin was used as a reference standard, prior to the administration of CCl4 to
rats. These findings indicate the protective potential of L. speciosa against hepato toxicity which
possibly involve mechanism related to its ability of selective inhibitors of (reactive oxygen species
like antioxidants brought about significant inhibition of TBARS suggesting possible involvement
of O2· -, HO2· , and ·OH. In conclusion, the amelioration may be attributed to the synergistic effects
of its constituents rather than to any single factor as the leaves are rich in tannins, sterols,
flavonoids, saponins etc.

참고문헌 (Reference)

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