최근 혈액에서 분리되는 칸디다 균종의 분리추이와 항진균제 감수성 = Isolation Trend and Antifungal Susceptibility of Candida Species Isolated from Blood Cultures

다국어 초록 (Multilingual Abstract)

Background : The frequency of nosocomial bloodstream infections by Candida species has risen dramatically in the past two decades, and a noticeable shift in the species of Candida causing bloodstream infection toward non-albicans species has occurred. Also, the isolation frequency of Candida species are infuenced by patient type, nation and region, study period, and investigators. The aim of this study is to investigate the isolation rates and antifungal susceptibility of Candida species isolated from blood cultures at Wonju Christian Hospital during the recent four years (1997-2000).
Methods : For one-hundred twenty-seven isolates of Candida species from blood cultures, we analyzed the isolation frequency by year, age/sex, and department. Identification of yeasts was done by germ tube test and ATB ID 32 C kit. Antifungal susceptibilities to flucytosine, amphotericin B, nystatin, miconazole, econazole, and ketoconazole were determined by ATB FUNGUS.
Results : The isolation rates of Candida species in decreasing order were C. albicans (44.9%), C. parapsilosis (21.3%), C. gkabrata (14.2%), and C. tropicalis (9.5%). The isolation rates of Candidα species by year were as follows; C. akbucabs decreased from 61.5% in 1997 to 33.3% in 2000; C. tropicalis decreased from 23.1% in 1997 to 5.0% in 2000; C. parapsilosis increased from 0% in 1997 to 30.8% in 2000; and C. glabrata increased from 7.7% in 1997 to 18.0% in 2000. Of 127 Candida species, all but one isolates were susceptible to amphotericin B.
Conclusion : This data showed that the candidemin by C. albicans and C. tropicalis are decreasing trend, and candidemia by C. parapsilosis and C. glabrata are increasing trend in recent four years. (Korean J Infect Dis 33:186∼193, 2001)

목차 (Table of Contents)

• 서론
• 재료 및 방법
• 결과
• 고찰
• 요약
• 참고문헌