융모막 융모샘플링(C.V.S)이 임산부 혈청 alpha-Fetoptrotein치에 미치는 영향에 관한 연구 = Detection of Fetomaternal hemorrhage (FMH) by measuring maternal serum alpha-Fetoptrotein (MSAFP) following chorionic villi sampling (CVS)

다국어 초록 (Multilingual Abstract)

FMH during CVS may contribute in subsequently raising the chance of abortion and even cause maternal Rh isoimmunization . Detection and quatitation of FMH could be made by determining the changes in MSAFP level by enzyme immunoassay before and 15 minutes after CVS. CVS was perfomred in 27 patients for prenatal genetic diagnosis using a flexible plastic catheter introduced transcervically under real-time ultrasonography guidance . MSAFP levels were analyzed comparatively according to their gestational weeks, amounts of villi sampled and the frequency of catheter-pass. Fifty-nine percent of these patients had an increaed MSAFP levels by 20 per cent or more. Such a rise was thought to reflect crossing of fetal blood through intervillous space upon performing CVS, A prospective correlation was obtained. The group given three to four catheter-passes had more elevated levels of MSAFP than the group given only one or two passes . In three of these patients more than 60 ul of fetal blood was transferred with only one of them presumed with more than 0.1ml of expected volume of FMH. To minimize the chance of FMH during CVS, a least amount of villi should be obtained for diagnosis with as few catheter-pass as possible.