탈감작법으로 치료한 인형 재조합 인슐린에 대한 아나필락시스 = A case of anaphylaxis to human recombinant insulin treated by desensitization

다국어 초록 (Multilingual Abstract)

Allergic reaction to insulin is mediated by several mechanisms; differences in amino acid sequence of animal and human insulin, altered tertiary structure of insulin and the presence of non-insulin protein contaminants or pharmaceutical additives. Anaphylactic reactions to insulin only occur in 0.1 to 2% of patients who stopped insulin therapy and have then resumed treatment. We report a diabetic patient who suffered severe anaphylactic reactions to human recombinant insulin, successfully treated by desensitization. A 19-year-old man with type 1 diabetes receiving Insulatard HM developed generalized urticaria and angioedema with progression to dyspnea, dizziness and syncope. Skin prick test to all kinds of human recombinant insulin products revealed immediate type hypersensitivity and the titer of insulin IgE was increased in serum. The desensitization trial with Velosulin HM using modified desensitization method was performed. Six months after the desensitization he was taking Velosulin HM as well as Insulatard HM without any evidence of systemic allergic reactions.(Korean J Med 62:204-208, 2002)

국문 초록 (Abstract)

인슐린 치료를 중단했다가 다시 재개한 제1형 당뇨병 환자에서 재조합 인형 인슐린에 대한 아나필락시스 반응이 발생하였으며, 이를 속효성 인형 인슐린을 이용하여 탈감작에 성공하였기에 보고한다.