홍삼.교맥 복합물의 미용식품 응용 가능성에 대한 연구 : 항산화 및 Collagenase 저해 효과 = A study on Application for Beauty Food of Mixture of Korean Red ginseng and Fagopyrum esculentum : Anti-oxidative Effect and Collagenase Inhibitory Activity

다국어 초록 (Multilingual Abstract)

Panax ginseng C.A. Meyer, Korean herb medicine, has been widely used in China and Japan for fatigue and enhancement of resistance to many diseases. In this study, we investigated the synergistic effect of Korean red ginseng and Fagopyrum esculentum extracts (RGFE) on dermal bioactive properties. RGFE treatment significantly increased electron donating ability, nitrite scavenging activity and collagenase inhibitory activity compared to red ginseng-treated group. Superoxide dismutase (SOD) activity in RGFE-treated group was similar to that of red ginseng. However, tyrosinase activity as indicator of melanin synthesis was not affected by RGFE or red ginseng. The results indicate that RGFE has anti-oxidative property and inhibitory effect of collagenase, and it may serve as a effective ingredient for beauty food.

참고문헌 (Reference)

1 소승호, "홍삼 생약 복합물(KTNG0345)의 피부 주름개선에 관한 작용기전" 고려인삼학회 32 (32): 39-47, 2008

2 박시향, "자외선 조사 무모쥐 피부조직에 도포한 애엽(Mugwort) 추출물의 주름개선 효과" 한국식품영양과학회 37 (37): 1136-1141, 2008

3 박수남, "메밀 추출물의 기능성 화장품으로서의 응용가능성에 대한 연구" 대한화장품학회 34 (34): 83-92, 2008

4 손호용, "메밀 종자의 항트롬빈 활성과 혈전증 예방효과" 한국식품영양과학회 35 (35): 132-138, 2006

5 김영언, "녹차, 메밀, 포도잎 추출물이 고콜레스테롤 급여 흰쥐의 지질대사, TBARS 및 혈액응고에 미치는 영향" 한국식품과학회 36 (36): 979-985, 2004

6 노성택, "교맥 에탄올 추출물의 피부 미백기전 연구" 대한동의병리학회 21 (21): 1243-1249, 2007

7 李京淳, "中藥大辭典" 정담 392-394, 1998

8 Chung S, "γ-Linolenic acid in borage oil reverses epidermal hyperproliferation in guinea pigs" 132 : 3090-3097, 2002

9 McCord JM, "The utility of superoxide dismutase in studying free radical reactions. I., Radicals generated by the interaction of sulfite, dimethyl sulfoxide, and oxygen" 25 : 6056-6063, 1963

10 Grant NH, "Studies on the collagenases of Clostridium histolyticum" 82 : 245-255, 1959

11 Ham SS, "Studies on antimutagenic and lipotropic action of flavonoids of buckwheat leaf extract" 23 : 698-703, 1994

12 Evans JL, "Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes" 23 : 599-622, 2002

13 Martinez­Esparza M, "Mechanism of melanogenesis inhibition by tumor necrosis factor ­alpha in B16/F10 mouse melanoma cells" 255 : 139-146, 1998

14 Marklund S, "Involvement of superoxide anion radical in the oxidation of pyrogallol and a convenient assay for superoxide dismutase" 47 : 468-474, 1975

15 Kato H, "Inhibitory of nitrosamine of formation by nondialyzable melanoidins" 1333-1337, 1987

16 Gray JI, "Inhibition of N-nitrosamine formation in model food system" 40 : 981-985, 1975

17 Choi YS, "In vitro screening of dietary factors on buckwheat(Fagopyrum esculentum Moench) influencing the regulation of blood pressure, glucose and cholesterol level" 29 : 280-287, 2000

18 Challis BC, "In the chemistry of amino, nitroso and nitro-compounds and their derivatrices" Wiley Inter Science 1151-, 1982

19 Lee EH, "Ginsenoside F1 protects human HaCaT keratinocytes from ultraviolaet-B-induced apoptosis by maintaining constant levels of Bcl-2" 121 : 607-613, 2003

20 최성원, "Epidermis Proliferative Effect of the Panax ginseng Ginsenoside Rb2" 대한약학회 25 (25): 71-76, 2002

21 Jung SL, "Effects of buckwheat on organ weight, glucose and lipid metabolism in streptozotocin-induced diabetic rats" 25 : 831-838, 1994

22 Miller CC, "Dietary supplementation with ethyl ester concentrates of fish oil (n-3) and borage oil (n-6) poly unsaturated fatty acid induces epidermal generation of local putative anti-inflammatory metabolites" 96 : 98-103, 1991

23 Kim SJ, "Compound K induces expression of hyaluronan synthetase 2 gene in transformed human keratinocytes and increases hyaluronan in hairless mouse skin" 316 : 348-355, 2004

24 Demina NS, "Collagenolytic enzymes synthesized by microorganism" 65 : 293-304, 1996

25 Suzanne EGF, "Collagen degradation in aged/photodamaged sin in vivo and after exposure to matrix metalloproteinase-1 in vitro" 120 : 842-848, 2003

26 Namiki MO, "Antioxidants/antimutagens in food" 29 : 273-300, 1990

27 Blois MS, "Antioxidant determination by the use of a stable free radical" 181 : 1199-1200, 1958

28 Tomomi M, "Antioxidant activies of buckwheat hull extract toward various oxidative stress in vitro and in vivo" 24 : 209-213, 2001

29 Kim CD, "Anti-allergic action of buckwheat (Fagopyrum esculentum Moench) grain extract" 3 : 129-136, 2003