Anti-inflammatory Effects of Sargachromanol I, Sargachromanol G, and Saringosterol from Hexane Fraction of Myagropsis myagroides

다국어 초록 (Multilingual Abstract)

The anti-inflammatory activity of benzopyran derivatives extracted from the Myagropsis myagroides against lipopolysaccharide (LPS)-induced RAW 264.7 murine macrophage cell line was examined. The three constituents of M. myagroides extracts were identified as the sargachromanol G, sargachromanol I, and saringosterol by 1H and 13C NMR. Sargachromanol G, sargachromanol I, and saringosterol at concentrations of 50 μg/mL showed inhibitory effects on LPS induced interleukin-6 production (by 84%, 90%, and 96%, respectively) and tumor necrosis factor (by 74%, 82%, and 98%, respectively). These results confirm the potential anti-inflammatory effects of sargachromanol G, sargachromanol I, and saringosterol.

참고문헌 (Reference)

1 전유진, "제주 자생 해양 녹조류와 갈조류 추출물로부터의 항고혈압 활성" 한국식품영양과학회 35 (35): 307-314, 2006

2 Ding, C., "Targeting IL-6 in the treatment of inflammatory and autoimmune diseases" 18 : 1457-1466, 2009

3 Kofler, S., "Role of cytokines in cardiovascular diseases : a focus on endothelial responses to inflammation" 108 : 205-213, 2005

4 Lee, J. H., "Preparative isolation of sargachromanol E from Sargassum siliquastrum by centrifugal partition chromatography and its antiinflammatory activity" 62 : 54-60, 2013

5 Senthilkumar, K., "Marine invertebrate natural products for anti-inflammatory and chronic diseases" 2013 : 572859-, 2013

6 박원민, "Inhibitory Effect of Hexane Fraction from Myagropsis myagroides on Pancreatic α-Amylase In Vitro" 한국미생물·생명공학회 25 (25): 328-333, 2015

7 Wächter, G. A., "Inhibition of Mycobacterium tuberculosis growth by saringosterol from Lessonia nigrescens" 64 : 1463-1464, 2001

8 Wong, C. K., "Hepatoprotective effect of seaweeds’ methanol extract against carbon tetrachloride-induced poisoning in rats" 512 : 267-270, 2004

9 Kim K. B., "Free radical scavenging activity and anticollagenase properties of sargachromanol I from Myagropsis myagroides" 81 : 561-565, 2019

10 Heo, S. J., "Evaluation of anti-inflammatory effect of fucoxanthin isolated from brown algae in lipopolysaccharide-stimulated RAW 264.7macrophages" 48 : 2045-2051, 2010

11 Jang, K. H., "Chromenes from the brown alga Sargassum siliquastrum" 68 : 716-723, 2005

12 Heo, S. J., "Chromene suppresses the activation of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 cells" 67 : 169-175, 2014

13 Chojnacka, K., "Biologically active compounds in seaweed extracts-the prospects for the application" 3 : 20-28, 2012

14 Yoon, W. J., "Artemisia fukudo essential oil attenuates LPS-induced inflammation by suppressing NF-kappaB and MAPK activation in RAW 264.7macrophages" 48 : 1222-1229, 2010

15 이소영, "Antimicrobial Activity of Myagropsis myagroides and Interaction with Food Composition" 한국식품과학회 20 (20): 85-92, 2011

16 Akihisa, T., "Antiinflammatory and anti-tumor-promoting effects of triterpene acids and sterols from the fungus ganoderma lucidum" 4 : 224-231, 2007

17 Athukorala, Y., "Anticoagulant activity of marine green and brown algae collected from Jeju Island in Korea" 98 : 1711-1716, 2007

18 Kim, S., "Anti-inflammatory effects of sargachromenol-rich ethanolic extract of Myagropsis myagroides on lipopolysaccharide-stimulated BV-2 cells" 14 : 231-, 2014

19 Joung, E. J., "Anti-inflammatory effects of phlorofucofuroeckol B-rich ethyl acetate fraction obtained from Myagropsis myagroides on lipopolysaccharide-stimulated RAW 264.7 cells and mouse edema" 14 : 471-480, 2012

20 Joung, E. J., "Anti-inflammatory effect of ethanolic extract from Myagropsis myagroides on murine macrophages and mouse ear edema" 12 : 171-, 2012

21 Jeong, D. H., "Anti-inflammatory activity of methanol extract and n-hexane fraction mojabanchromanol b from Myagropsis myagroides" 114 : 12-19, 2014

22 Weon Jong Yoon, "Anti-inflammatory Effect of Sargachromanol G Isolated from Sargassum siliquastrum in RAW 264.7 Cells" 대한약학회 35 (35): 1421-1430, 2012

23 Luo, X., "Advances in microalgaederived phytosterols for functional food and pharmaceutical applications" 13 : 4231-4254, 2015

24 Chen, Z., "24(S)-Saringosterol from edible marine seaweed Sargassum fusiforme is a novel selective LXRβ agonist" 62 : 6130-6137, 2014

25 김꽃봉우리, "2,4-Dinitrochlorobenzene 유도 아토피 피부염 모델 마우스에 대한 외톨개 모자반(Myagropsis myagroides) 에탄올 추출물의 억제 효과" 한국식품영양과학회 44 (44): 1121-1127, 2015