광자극에 의한 일주기 교란 모델에서 전침의 간 염증 반응과 소포체 스트레스 회복 가능성|RISS 상세보기

다국어 초록 (Multilingual Abstract)

Objectives: Oriental medicine emphasizes circadian rhythm for maintaining health by balancing yin and yang energy. This study aims to investigate whether acupuncture treatment can recover liver dysfunction and inflammation-related indicators disrupted by photostimulation.
Methods and Results: Continuous exposure to 150 Lux of light for 4 weeks extended the circadian rhythm of experimental animals from 23.95 hours to 26.6 hours. Zeitgeber 9 (ZT9) and ZT21 were selected as representative times of day and night, and blood was collected for analysis. Results showed that White Blood Cell(WBC) and lymphocyte counts decreased at ZT21 compared to ZT9, and these changes were restored after 3 weeks of acupuncture treatment at ZT21. In liver tissue, chemokines RANTES and CXCL7, altered by constant light exposure(CCL), were also restored by acupuncture treatment at HT7 and ST36. Additionally, pro-inflammatory cytokines IL-6 and IL-1β were increased in the CCL group, but immune and inflammatory responses improved after acupuncture treatment at HT7 and ST36. As for endoplasmic reticulum stress, which regulates inflammatory cytokine expression, the expression of Bip, a protein that increases with protein folding abnormalities, was elevated in the CCL group but restored to ZT21 levels by acupuncture treatment. However, while proteins involved in apoptosis showed a decreasing trend in the CCL group, recovery through acupuncture treatment was not statistically confirmed.
Conclusions: This study concludes that electroacupuncture at HT7 and ST36 can regulate blood and liver inflammation, as well as endoplasmic reticulum stress, in circadian rhythm disruption caused by photostimulation. It highlights a non-pharmacological approach to recovery.

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