Influence of Ovariectomy on Bone Turnover and Trabecular Bone Mass in Mature Cynomolgus Monkeys

다국어 초록 (Multilingual Abstract)

Purpose: To examine the influence of ovariectomy (OVX) on bone turnover and trabecular bone mass at the 3
clinically important skeletal sites in mature cynomolgus monkeys. Materials and Methods: Six female
cynomolgus monkeys, aged 17-21 years, were randomized into 2 groups by the stratified weight: the OVX and
sham-operation groups (n = 3 in each group). The experimental period was 16 months. Lumbar bone mineral
density (BMD) in vivo and serum and urinary bone turnover markers were longitudinally measured, and peripheral
quantitative computed tomographic and bone histomorphometric analyses were performed on trabecular bone of the
lumbar vertebra, femoral neck, and distal radius at the end of the experiment. Results: OVX induced in a reduction
in lumbar BMD compared with the sham controls and the baseline, as a result of increased serum levels of bonespecific
alkaline phosphatase and urinary levels of cross-lined N- and C-terminal telopeptides of type I collagen.
Furthermore, OVX induced reductions in trabecular volumetric BMD and trabecular bone mass compared with the
sham controls, with increased bone formation rate at the lumbar vertebra, femoral neck, and distal radius.
Conclusion: The results indicated that OVX in mature cynomolgus monkeys (17-21 years of age) increased bone
turnover and induced trabecular bone loss at the three skeletal sites compared with the sham controls. Thus, mature
cynomolgus monkeys could be utilized for preclinical studies to examine the effects of interventions on bone
turnover and trabecular bone mass at the 3 clinically important skeletal sites.

다국어 초록 (Multilingual Abstract)

Purpose: To examine the influence of ovariectomy (OVX) on bone turnover and trabecular bone mass at the 3
clinically important skeletal sites in mature cynomolgus monkeys. Materials and Methods: Six female
cynomolgus monkeys, aged 17-21 years, were randomized into 2 groups by the stratified weight: the OVX and
sham-operation groups (n = 3 in each group). The experimental period was 16 months. Lumbar bone mineral
density (BMD) in vivo and serum and urinary bone turnover markers were longitudinally measured, and peripheral
quantitative computed tomographic and bone histomorphometric analyses were performed on trabecular bone of the
lumbar vertebra, femoral neck, and distal radius at the end of the experiment. Results: OVX induced in a reduction
in lumbar BMD compared with the sham controls and the baseline, as a result of increased serum levels of bonespecific
alkaline phosphatase and urinary levels of cross-lined N- and C-terminal telopeptides of type I collagen.
Furthermore, OVX induced reductions in trabecular volumetric BMD and trabecular bone mass compared with the
sham controls, with increased bone formation rate at the lumbar vertebra, femoral neck, and distal radius.
Conclusion: The results indicated that OVX in mature cynomolgus monkeys (17-21 years of age) increased bone
turnover and induced trabecular bone loss at the three skeletal sites compared with the sham controls. Thus, mature
cynomolgus monkeys could be utilized for preclinical studies to examine the effects of interventions on bone
turnover and trabecular bone mass at the 3 clinically important skeletal sites.

참고문헌 (Reference)

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