한국인의 심근 조직내 카드뮴 농도의 참고치 = Reference Value of Cadmium in Myocardium in Korean

다국어 초록 (Multilingual Abstract)

Cadmium(Cd) is an ubiquitous, toxic and nonessential metal which is controversial about the association with a cardiovascular disease. In this study, we investigated the reference level of Cd in myocardium in Korean general population. The level of Cd and zinc(Zn) concentration in myocardium of 252 cases of "sudden and unexpected death" autopsies (male: 172, female : 60) aged 0 to 87 years was analyzed. The concentration of Cd and Zn was determined with atomic absorption spectrophotometer(Perkin-Elmer Model 5100) by flameless and flame method, respectively.
The content of Cd and Zn in myocardium showed the log-normal distribution rather than normal distribution. Geometric mean concentration of Cd was 0.19 ㎍/g wet weight in myocardium. The level of Cd in myocardium was not significantly different between male (0.18㎍/g wet weight) and female (0.22㎍/g wet weight). Geometric mean concentration of Zn in myocardium was 25.25 ㎍/g wet weight. The level of Zn between male (25.13 ㎍/g wet weight) and female (25.57㎍/g wet weight) was not different. The deposit of Cd in myocardium was age-dependent of biphasic pattern, but the Zn level by age was not significantly different. The level of Cd in myocardium was increased to the fifties of age, thereafter a leveling-off was shown. The regression model of Cd deposit in myocardium by age was predicted as the following equation: Log Heart-Cd= -1.2726 + 0.0234 ·Age -0.0002 ·Age². The maximum Cd deposit in myocardium was estimated to be 0.26 ㎍/g wet weight at the age of 58.5 in Korean general population. In addition, the total Cd burden in heart by age was predicted as a following equation: Total Cd burden in Heart= -10.165+2.891 ·Age -0.0258 ·Age². The maximum heart burden of Cd was estimated to be 70.7㎍ at age of 55.4. The positive correlation between Cd and Zn was observed in myocardium. The linear regression equation was Log Heart-Zn = 1.4195+0.0262 ·Log Heart-Cd.

목차 (Table of Contents)

• -Abstract-
• 서 론
• 연구대상 및 방법
• 1. 조사대상
• 2. 시료채취 및 분석
• (1) 시료채취
• (2) 시료 전처리
• (3) 중금속 분석
• 3. 자료정리 및 분석
• 연구결과
• 1. 조사대상자의 일반적 특성
• 2. 심근 조직내 카드뮴과 아연의 평균농도
• 3. 연령군에 따른 심근 조직내 카드뮴과 아연농도
• 4. 연령에 따른 심근 조직내 카드뮴농도의 추정
• 5. 심근 조직내 카드뮴과 아연과의 관계
• 고 찰
• 결 론
• 인용문헌