빈뇨와 복통, 설사로 발현된 방광과 위장관을 동시 침범한 과호산구증가증후군 1예 = CASE REPORT : Idiopathic hypereosinophilic syndrome presenting with urinary frequency, abdominal pain, and diarrhea

다국어 초록 (Multilingual Abstract)

Idiopathic hypereosinophilic syndrome (IHES) is a rare disorder defined by persistent blood eosinophilia, evidence of eosinophil-associated organ dysfunction and absence of secondary causes. Eosinophilic infiltration and its mediator release can cause damage to multiple organs. Although IHES can involve every organ system, bladder involvement is rarely evidenced. We recently reported a case of IHES with both bladder and gastrointestinal tract involvement. A 43-year-old woman visited Hallym University Sacred Heart Hospital complaining of urinary frequency, abdominal pain, and diarrhea for several months. Abdominal pelvic computed tomographic scan showed diffuse wall thickenings in her bladder and colon with small pelvic ascites. Laboratory investigation showed a marked peripheral eosinophilia and tissue biopsies confirmed eosinophilic infiltration in the bladder wall, esophagus, and duodenum. The patient was treated with prednisolone and her eosinophilia and symptoms have gradually improved.

참고문헌 (Reference)

1 조윤주, "호산구 식도염: Update 2012" 대한소화기학회 60 (60): 3-12, 2012

2 정윤진, "야간뇨와 호흡곤란으로 발현된 신장을 침범한 특발성 호산구 증가 증후군 1예" 대한천식알레르기학회 30 (30): 241-245, 2010

3 Gotlib J., "World Health Organization-defined eosinophilic disorders: 2014 update on diagnosis, risk stratification, and management" 89 : 325-337, 2014

4 Rothenberg ME, "Treatment of patients with the hypereosinophilic syndrome with mepolizumab" 358 : 1215-1228, 2008

5 Razaq W, "Successful treatment of refractory idiopathic hypereosinophilic syndrome with etoposide" 16 : 68-70, 2009

6 Arefi M, "Response to imatinib mesylate in patients with hypereosinophilic syndrome" 96 : 320-326, 2012

7 Simon HU, "Refining the definition of hypereosinophilic syndrome" 126 : 45-49, 2010

8 Roufosse F, "Practical approach to the patient with hypereosinophilia" 126 : 39-44, 2010

9 Podjasek JC, "Mortality in hypereosinophilic syndrome : 19 years of experience at Mayo Clinic with a review of the literature" 37 : 392-395, 2013

10 Ogbogu PU, "Hypereosinophilic syndrome: a multicenter, retrospective analysis of clinical characteristics and response to therapy" 124 : 1319-1325.e3, 2009

11 Ingle SB, "Eosinophilic gastroenteritis : an unusual type of gastroenteritis" 19 : 5061-5066, 2013

12 Kojima K, "Eosinophilic cystitis presented as a manifestation of hypereosinophilic syndrome : a case report and review of the literature" 3 : 30-35, 2013

13 Manimaran D, "Eosinophilic cystitis mimicking bladder tumour-a rare case report" 7 : 2282-2283, 2013

14 Itano NM, "Eosinophilic cystitis in adults" 165 : 805-807, 2001

15 Valent P, "Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes" 130 : 607-612.e9, 2012

16 Cogan E, "Clinical management of the hypereosinophilic syndromes" 5 : 275-289, 2012

17 Helbig G, "Advances in the diagnosis and treatment of eosinophilia" 21 : 3-7, 2014

18 Lee SI, "A case of eosinophilic gastroenteritis diagnosed by repeated abdominal pain with eosinophilic ascites and cystitis" 26 : 191-195, 2011

19 Kim SS, "A case of eosinophilic enterocolitis associated with eosinophilic ascites and cystitis" 69 (69): S746-S752, 2005