류마토이드 관절염 환자에 대한 Recombinant Interferon Gamma 의 임상시험 = Clinical Trial on Treatment of Rheumatoid Arthritis with Recombinant Interferon - Gamma류마토이드 관절염 환자에 대한 Recombinant Interferon Gamma 의 임상시험

다국어 초록 (Multilingual Abstract)

To evaluate antirheumatic efficacies and possibilities on treatment of rheumatoid arthritis with recombinant interferon-gamma, 44 patients with rheumatoid arthritis were treated with IFN-γ for 20 days and were analysed from the standpoint of Ritchie index, patient's assessment, laboratory findings and sideffect. The observed results are as follows: 1) 44 patients were enrolled, 40 patients could be evaluated. Of these, 22 were responders (55%) according to the criteria for treatment success. 2) In 35 patients, stabilized therapy was continued concomittant with the IFN-γ and were no significant differences with respect to the results of treatment. 3) In responders, Ritchie index decreased from 28 on the day of recruitment into the study to 15 on day 20. 4) The patients evaluation of morning pain and change in mobility showed more improvements in responders than non-responders. 5) Monitering of laboratory parameters revealed no therapeutically relevant changes. Side-effects occurred in 14 out of 40 patients. In 10 of these patients, transient fever was recorded.