리팍시민이 흰쥐의 의액분비 및 생쥐의 소장수송능에 미치는 영향 = Effect of Rifaximin on the Gastric Juice Secretion in Rats and the Gastrointestinal Motility in Mice

다국어 초록 (Multilingual Abstract)

Rifaximin, the active ingredient in Normix??, has an extremely broad spectrum of action covering all intestinal germs and its absorption is practically zero. It is not appreciably absorbed through the gastrointestinal(GI) tract and not inactivated by gastric juice and is eliminated unchanged in stools. General pharmacology of rifaximin has not been studied sufficiently due to its negligible absorption. In this study, the effect of rifaximin on the gastric juice secretion was investigated in rats and its effect on the gastrointestinal motility was also investigated in mice. Rifaximin had no effect on pH, volume, acidity and pepsin activity of gastric juice in rats and also no effect on GI motility(charcoal transport) in mice. Therefore, rifaximin may have little effect on the GI tract.