The Korean Academy of Tuberculosis and Respiratory Diseases : Slide Session ; OS-056 : COPD ; Gender and the Prevalence of COPD in Korean Adult Smokers: A Population-Based Study = The Korean Academy of Tuberculosis and Respiratory Diseases : Slide Session ; OS-056 : COPD ; Gender and the Prevalence of COPD in Korean Adult Smokers: A Population-Based Study

다국어 초록 (Multilingual Abstract)

Background: The objective of this study was to investigate smoking effect on gender and the prevalence of chronic obstructive pulmonary disease (COPD). Method: Data for this study were obtained from Korean National Health and Nutrition Examination Survey (KNHANES) from 2007 to 2012 containing demographics, smoking histories and spirometry data. We recruited 6,159 ever-smokers (male 5,543 and female 616) aged over 40 who adequately performed spirometry according to American Thoracic Society (ATS) guidelines. Subjects with FEV1/FVC<0.7 were defi ned as COPD. To evaluate the loss of lung function per pack-year smoked, we used susceptibility index (SI), calculated using the formula: (% predicted FEV1 - 100)/pack-years. Results: Mean age was lower in male than female (56.7 vs. 58.0, p<0.001) and total amount of smoking expressed as a pack-year was greater in male than female (25.7 vs. 11.0, p<0.001). Total 1,453 (23.6%) subjects were diagnosed with COPD. Even though the prevalence of COPD was higher in male (24.5%) than female (5.4%)(p<0.001), female showed more loss of lung function per pack-year smoked than male (SI in female = -1.43% vs. SI in male= -0.79, p<0.001). To evaluate smoking effect precisely, 3,440 subjects (male 3,337 and female 103) who smoked more than 20 pack-years through life were selected. Mean age was also lower in male than women (57.7 vs. 63.7, p<0.001) and total amount of smoking (pack-year) was greater in male than female (36.3 vs. 31.8, p=0.0029). However the prevalence of COPD was not different between in male (29.0%) and in females (24.3%) (p=0.567). Female stillshowed more loss of lung function per pack-year smoked than male (SI in female = -0.56% vs. SI in male = -0.39, p=0.0003). Conclusion: Korean female ever-smokers have a susceptibility to smoking effect on lung function decline.