RISS 검색 - 국내학술지논문 상세보기

다국어 초록 (Multilingual Abstract)

Background and Purpose Blood pressure (BP) control is strongly recommended, but BP control rate has not been well studied in patients with stroke. We evaluated the BP control rate with fimasartan-based antihypertensive therapy initiated in patients with recent cerebral ischemia.
Methods This multicenter, prospective, single-arm trial involved 27 centers in South Korea.
Key inclusion criteria were recent cerebral ischemia within 90 days and high BP [systolic blood pressure (SBP) >140 mm Hg or diastolic blood pressure (DBP) >90 mm Hg]. BP lowering was initiated with fimasartan. BP management during the follow-up was at the discretion of the responsible investigators. The primary endpoint was the target BP goal achievement rate (<140/90 mm Hg) at 24 weeks. Key secondary endpoints included achieved BP and BP changes at each visit, and clinical events (ClinicalTrials.gov Identifier: NCT03231293).
Results Of 1,035 patients enrolled, 1,026 were included in the safety analysis, and 951 in the efficacy analysis. Their mean age was 64.1 years, 33% were female, the median time interval from onset to enrollment was 10 days, and the baseline SBP and DBP were 162.3±16.0 and 92.2±12.4 mm Hg (mean±SD). During the study period, 55.5% of patients were maintained on fimasartan monotherapy, and 44.5% received antihypertensive therapies other than fimasartan monotherapy at at least one visit. The target BP goal achievement rate at 24-week was 67.3% (48.6% at 4-week and 61.4% at 12-week). The mean BP was 139.0/81.8±18.3/11.7, 133.8/79.2±16.4/11.0, and 132.8/78.5±15.6/10.9 mm Hg at 4-, 12-, and 24-week. The treatment- emergent adverse event rate was 5.4%, including one serious adverse event.
Conclusions Fimasartan-based BP lowering achieved the target BP in two-thirds of patients at 24 weeks, and was generally well tolerated.

참고문헌 (Reference)

1 Choung YH, "‘Bow and lean test’to determine the affected ear of horizontal canal benign paroxysmal positional vertigo" 116 : 1776-1781, 2006

2 Strupp M, "including gaze palsy and nystagmus" 261 (261): S542-S558, 2014

3 Lee SU, "Windmill nystagmus in a patient with subacute visual loss" 265 : 2737-2739, 2018

4 Choo OS, "Vertical nystagmus in the bow and lean test may indicate hidden posterior semicircular canal benign paroxysmal positional vertigo : hypothesis of the location of otoconia" 10 : 6514-, 2020

5 Kattah JC, "Vertical nystagmus in Wernicke’s encephalopathy : pathogenesis and role of central processing of information from the otoliths" 266 : 139-145, 2019

6 Fath L, "Unusual locations of benign paroxysmal positional vertigo : rare entity or regular occurrence?" 41 : e735-, 2020

7 Huh SY, "The usefulness of brain MRI at onset in the differentiation of multiple sclerosis and seropositive neuromyelitis optica spectrum disorders" 20 : 695-704, 2014

8 Dumas G, "The skull vibration-induced nystagmus test of vestibular function-a review" 8 : 41-, 2017

9 Sinno S, "The skull vibration-induced nystagmus test : a useful vestibular screening test in children with hearing loss" 137 : 451-457, 2020

10 Oman CM, "The physiological range of pressure difference and cupula deflections in the human semicircular canal. Theoretical considerations" 74 : 324-331, 1972