근위축성측삭경화증의 전기생리학적 특징 : 신경전도검사 = Electrophysiological evaluation of Amyotrophic Lateral Sclerosis ; Nerve Conduction Studies

다국어 초록 (Multilingual Abstract)

OBJECTIVES: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder, characterized by a selective progressive degeneration of the motor system. Electromyography is essential for the diagnosis of ALS. The measurement of motor conduction of peripheral nerves is of major importance to recognize other possible causes of progressive muscle wasting. Never conduction study (NCS) is an objective, quantitative, and reproducible measure of peripheral nervous function and has been widely used for the differential diagnosis of nervous disease. METHODS: In this study we analyze the values of motor nerve conduction studies and sensory nerve conduction studies were performed; distal motor latency (DML), compound muscle action potential (CMAP), motor nerve conduction velocity (MNCV), compound nerve action potential and sensory nerve conduction velocity in 82 patients with definite ALS. RESULTS: We found slight slowing of SNCV and moderate to strong reduction of CMAP, MNCV and a prolongation of DML. We found no significant change No potential and conduction block between ALS and control. CONCLUSIONS: The main finding of the present work was moderate to strong reduction of motor nerve and slight sensory involvement in ALS. And NCS do not seem to be a sole measure to the end because they sometimes showed undistinguishable results. Accordingly, more researches on electrophysiology characteristics of NCS in ALS should be carried out for its precise clinical application in the future.

목차 (Table of Contents)

• Abstract
• Ⅰ. 서론
• Ⅱ. 연구방법
• Ⅲ. 결과
• Ⅳ. 논의
• Ⅴ. 결론
• 참고문헌

참고문헌 (Reference)

1 이광우, "신경과학" 범문사 2005

2 Shaw PJ, "Science, medicine and the future, motor neuron disease" 318 : 1118-1121, 1999

3 Al Chalabi A, "Recent advances in amyotrophic lateral sclerosis" 13 : 397-405, 2000

4 Mills KR, "Peripheral and central conduction in amyotrophic lateral sclerosis" 159 : 82-87, 1998

5 Mamede C, "Nerve conduction studies in amyotrophic lateral sclerosis" 23 : 344-352, 2000

6 Ghezzi A, "Multimodality evoked potentials in amyotrophic lateral sclerosis" 79 : 353-356, 1989

7 Wilhelm J, "Focal sensory nerve abnormalities in patients with amyotrophic lateral sclerosis" 16 (16): 189-193, 1999

8 Emery AEH, "Familial motor neuron disease. Human motor neuron disease. Advances in neurology, Vol.36" Raven Press 139-147, 1982

9 Andreas AA, "F wave study in amyotrophic lateral sclerosis. Assessment of balance between upper and lower motor neuron involvement" 117 : 1260-1265, 2006

10 Theys PA, "Evolution of motor and sensory deficits in amyotrophic lateral sclerosis estimated by neurophysiological techniques" 246 : 438-442, 1999

11 M. Hammad, "Clinical, electrophysiologic, and pathologic evidence for sensory abnormalities in ALS" 69 : 2236-2242, 2007

12 Andrew E, "Clinical neurophysiology of ALS" 112 : 2190-2201, 2001

13 Oh SJ, "Clinical electromyography. Nerve conduction studies, Third edition" Lippincott Williams & Wilkins 2003

14 Argyriou AA, "Clinical and epidemiological features of motor neuron disease in south-western Greece" 111 (111): 108-113, 2005

15 Daniel MF, "Amplitude-dependent slowing of conduction in amyotrophic lateral sclerosis and polyneuropathy" John Wiley & Sons. Inc 1999

16 Matheson JK, "Abnormalities of multimodality evoked potentials in amyotrophic lateral sclerosis" 43 : 338-340, 1986

17 Shefner JM, "Abnormalities in the sensory action potential in patients with amyotrophic lateral sclerosis" 14 : 1242-1246, 1991

18 Radtke RA, "Abnormal sensory evoked potentials in amyotrophic lateral sclerosis" 36 : 796-800, 1986