Cysteamine 투여에 의하여 유발된 흰쥐의 소화성궤양 (消化性潰瘍) 모델에서 위점막내 (胃粘膜內) G 세포 및 혈중 개스트린 농도의 변화에 대한 실험적 연구 = Gastric G Cell Population and Serum Gastrin Level in Cysteamine - Induced Gastro - Duodenal Ulcer Model in RatsCysteamine 투여에 의하여 유발된 흰쥐의 소화성궤양 (消化性潰瘍) 모델에서 위점막내 (胃粘膜內) G 세포 및 혈중 개스트린 농도의 변화에 대한 실험적 연구

다국어 초록 (Multilingual Abstract)

Authors established an experimental model of peptic ulcer in rats by means of subcutaneous administration of 23 mg cysteamine per 100 g body weight. The lesions were found in the pyloric antrum and duodenum, and their pathologic features corresponded to those in human ones. Gastric G-cell population patterns were studied by immunohistochemical method using anti-gastrin peroxidase-antiperoxidase, and correlated with serum gastrin level. Total number of gastric G-cells were decreased 3 hours after cysteamine injection but showed their rebound in 3 days, while serum gastrin level were increased 3 hours after cysteamine injection. The mucosal areas containing G-cells were markedly reduced after cysteamine injection followed by long term oral administration. The above findings suggest that the ulcerogenic effect of cysteamine is mediated by gastrin.