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      림프세포증식성 질환에서 효과를 보인 부분적 비동맥 색전술 1례 = Successful Treatment with Partial Splenic Embolization in a Case of Post-transplantations Lymphoproliferative Disease with Persistent Hypersplenism

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      https://www.riss.kr/link?id=A101972397

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      다국어 초록 (Multilingual Abstract)

      Posttranplantations lymphoproliferative disease (PTLD) is a common and life-threatening complication for soid organ transplantation associated with the use of chronic immunosuppression and Epstein-Barr virus. There is no standardized treatment algorithm, but numerous management strategies are vaiable. Partial splenic embolization (PSE) had been demonstrated to be an effetive alternatie to splenectomy for patients hypersplenism and portal hypertension. PSE has the advantages of non-invasive intervention and resolution of the complications of hypersplenism. We report the effect of the PSE in a 6-year old male liver transplantation recepient with PTLD who has undergone persistent hypersplenism post-transplant. We reduced immunosuppression agent, started antiviral agent. We started with interferon and IV globulin one month after admission. Hepatosplenomegaly and cervical lymphadenopathy were improved. But fever was not subside. We selectively embolized the lower pole of the spleen to achieve a 50~60% reduction in flow as determined by angiography. After embolization, fever subside and peripheral blood findings were improved. Follow up abdominal CT revealed reduced volume of spleen due to ischemic change and there was no multiple enlarged mesenteric lymphnode compared to preembolization state. We thick that PSE is a safe an effetive treatment modality of PTLD with persistent hypersplenism in patients twho failed to medical treatment.
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      Posttranplantations lymphoproliferative disease (PTLD) is a common and life-threatening complication for soid organ transplantation associated with the use of chronic immunosuppression and Epstein-Barr virus. There is no standardized treatment algorit...

      Posttranplantations lymphoproliferative disease (PTLD) is a common and life-threatening complication for soid organ transplantation associated with the use of chronic immunosuppression and Epstein-Barr virus. There is no standardized treatment algorithm, but numerous management strategies are vaiable. Partial splenic embolization (PSE) had been demonstrated to be an effetive alternatie to splenectomy for patients hypersplenism and portal hypertension. PSE has the advantages of non-invasive intervention and resolution of the complications of hypersplenism. We report the effect of the PSE in a 6-year old male liver transplantation recepient with PTLD who has undergone persistent hypersplenism post-transplant. We reduced immunosuppression agent, started antiviral agent. We started with interferon and IV globulin one month after admission. Hepatosplenomegaly and cervical lymphadenopathy were improved. But fever was not subside. We selectively embolized the lower pole of the spleen to achieve a 50~60% reduction in flow as determined by angiography. After embolization, fever subside and peripheral blood findings were improved. Follow up abdominal CT revealed reduced volume of spleen due to ischemic change and there was no multiple enlarged mesenteric lymphnode compared to preembolization state. We thick that PSE is a safe an effetive treatment modality of PTLD with persistent hypersplenism in patients twho failed to medical treatment.

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      참고문헌 (Reference)

      1 "Two cases of posttransplant lymphoproliferative disorders in recipients of liver transplantation" 56 : 399-402, 1999

      2 "The role of immunosuppression in lymphoma formation" 20 : 343-355, 1998

      3 "The involvement of the gastrointestinal tract in posttransplant lymphoproliferative disease in pediatric liver transplantation" 28 : 380-385, 1999

      4 "The frequency of Epstein-Barr virus infection and associated lymphoproliferative syndrome after transplantation,and its manifestations in children" 45 : 719-27, 1988

      5 "The antiviral prophylaxis of posttransplant lymphoproliferative disorder" 20 : 437-453, 1998

      6 "Post-transplant lymphoproliferative disease in children" 154 : 250-257, 2001

      7 "Partial splenic embolization:long-term outcome" 387 : 421-426, 2003

      8 "Partial splenic embolization for hypersplenism before and after transplantation" 16 (16): 59-61, 2002

      9 "Lymphoproliferative disorders after organ transplantation in children" 67 : 990-998, 1999

      10 "Lymphoproliferative disease after lung transplantation in transplanted lung" 34 : 956-959, 2001

      1 "Two cases of posttransplant lymphoproliferative disorders in recipients of liver transplantation" 56 : 399-402, 1999

      2 "The role of immunosuppression in lymphoma formation" 20 : 343-355, 1998

      3 "The involvement of the gastrointestinal tract in posttransplant lymphoproliferative disease in pediatric liver transplantation" 28 : 380-385, 1999

      4 "The frequency of Epstein-Barr virus infection and associated lymphoproliferative syndrome after transplantation,and its manifestations in children" 45 : 719-27, 1988

      5 "The antiviral prophylaxis of posttransplant lymphoproliferative disorder" 20 : 437-453, 1998

      6 "Post-transplant lymphoproliferative disease in children" 154 : 250-257, 2001

      7 "Partial splenic embolization:long-term outcome" 387 : 421-426, 2003

      8 "Partial splenic embolization for hypersplenism before and after transplantation" 16 (16): 59-61, 2002

      9 "Lymphoproliferative disorders after organ transplantation in children" 67 : 990-998, 1999

      10 "Lymphoproliferative disease after lung transplantation in transplanted lung" 34 : 956-959, 2001

      11 "Long-term results of initial and repeated partial splenic embolizaton for the treatment of chronic idiopathic thrombocytopenic purpura" 179 : 1323-1326, 2002

      12 "Long-term hematolgical and biochemical effects of partial splenic embolization in hepatic cirrhosis" 49 : 1445-1448, 2002

      13 "Interferon-α treatment posttransplant lymphoproliferative disorder in recipients of solid organ transplants" 66 : 1770-1779, 1998

      14 "Indications and results of chemotherapy in children with posttransplant lymphoproliferative disease after liver transplantation" 69 : 9982-9984, 2001

      15 "Expression of Epstein-Barr virus-encoded small RNA(by the EBER- 1 gene)in liver specimens from transplant recipients with post-transplantation lymphoproliferative disease" 327 : 1710-4, 1992

      16 "Epstein-Barr virus and post- transplant lymphoproliferative disease" 6 : 456-464, 2002

      17 "Embolization of the spleen for treatment of splenomegaly and hypersplenism in patients with portal hypertension" 14 : 457-64, 1979

      18 "Changes in portal hemodynamics and hepatic function after partial splenic embolization" 33-41,

      19 "An increased incidence of Epstein-Barr virus infection and lymphoproliferative disorder in young children on FK 506 after liver transplantation" 59 : 524-529, 1995

      20 "A case of posttransplant lymphoproliferative disease(PTLD)following renal transplantation in a child" 6 : 123-130, 2002

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2023 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2020-01-01 평가 등재학술지 유지 (해외등재 학술지 평가) KCI등재
      2013-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2012-04-03 학술지명변경 한글명 : 대한소아소화기영양학회지 -> Pediatric Gastroenterology, Hepatology & Nutrition
      외국어명 : Korean J Pediatr Gastroenterol Nutr -> Pediatric Gastroenterology, Hepatology & Nutrition
      KCI등재
      2010-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2007-07-06 학회명변경 영문명 : The Korean Society Of Pediatric Gastroenterology And Nutrition -> The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition KCI등재
      2007-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2006-06-27 학술지명변경 외국어명 : 미등록 -> Korean J Pediatr Gastroenterol Nutr KCI등재후보
      2006-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2005-05-30 학술지등록 한글명 : 대한소아소화기영양학회지
      외국어명 : 미등록
      KCI등재후보
      2005-01-01 평가 등재후보 1차 FAIL (등재후보1차) KCI등재후보
      2003-07-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.07 0.07 0.09
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.09 0.1 0.367 0.03
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