선천성 기억 T 세포 미분화로 인해 반복적인 Tonsillitis를 보인 31세 여자 환자 1예 = A Case of 31-Year-Old Female With Recurrent Tonsillitis due to Poor Differentiation of Naïve T Cells to Memory T Cells

다국어 초록 (Multilingual Abstract)

We report a case of a 31-year-old female presented with recurrent sore throat and dyspneaeven after tonsillectomy and repeated adenoidectomy. Hypertrophic lingual tonsil was re-moved via transoral robotic surgery and was confirmed as lymphoid follicular hyperplasia bypathological examination. The analysis of the distribution and the mean fluorescence intensityof T cells after stimulation with relevant cytokines showed impaired differentiation of naïve Tcells into memory T cells. As such, defective T cell immunity had made the patient suscepti-ble to repetitive upper respiratory infection.

참고문헌 (Reference)

1 Cerottini JC, "The cellular basis of T-cell memory" 7 : 77-89, 1989

2 Dutton RW, "T cell memory" 16 : 201-223, 1998

3 Sponzilli I, "Severe combined immunodeficiency(SCID) : From molecular basis to clinical management" 82 (82): 5-13, 2011

4 Dan JM, "Recurrent group A Streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant TFH cells" 11 (11): eaau3776-, 2019

5 Abdel-Naby Awad OG, "Prevalence of humoral immunodeficiency in adult patients with recurrent tonsillitis" 40 (40): 102275-, 2019

6 Veldhoen M, "Interleukin 17 is a chief orchestrator of immunity" 18 (18): 612-621, 2017

7 Farber DL, "Immunological memory : Lessons from the past and a look to the future" 16 (16): 124-128, 2016

8 Meng HX, "Immunoglobulin and CD8+ T-cell distribution in histologically distinctive tonsils of individuals with tonsillar focal infection" 135 (135): 264-270, 2015

9 Paul WE, "History of interleukin-4" 75 (75): 3-7, 2015

10 Cowan MJ, "Hematopoietic stem cell transplantation for severe combined immunodeficiency diseases" 14 (14): 73-75, 2008

11 Geißler K, "Functional characterization of T-cells from palatine tonsils in patients with chronic tonsillitis" 12 (12): e0183214-, 2017

12 Roberts AD, "Differential contributions of central and effector memory T cells to recall responses" 202 (202): 123-133, 2005

13 Geißler K, "Cytokine production in patients with recurrent acute tonsillitis : Analysis of tonsil samples and blood" 10 (10): 13006-, 2020

14 Monafo WJ, "A hereditary immunodeficiency characterized by CD8+ T lymphocyte deficiency and impaired lymphocyte activation" 90 (90): 390-393, 1992

15 Tchilian EZ, "A deletion in the gene encoding the CD45 antigen in a patient with SCID" 166 (166): 1308-1313, 2001