키토산 나노 섬유 지지체의 제작과 생체공학적 응용 = Fabrication of Chitosan Nanofiber Scaffold and Their Biomedical Applications

다국어 초록 (Multilingual Abstract)

Functional biomaterial research has been directed toward the development of improved scaffolds for tissue engineering.
Many biodegradable and biocompatible polymers both synthetic polymers and natural polymers have been used to make scaffolds. Among the naturally derived polymers, chitosan which is deacetylated derivative of chitin, is widely used for biomedical applications such as tissue engineering scaffolds, drug delivery, and wound dressing due to their unique biological properties such as biocompatibility, biodegradability, anti-bacterial, and non-toxicity. In the recent years, electrospinning has been used to be a novel technique to fabricate nano/micro fibers. These nano/micro fibers have been applied in biomedical fields as tissue engineering scaffold because of their high surface area and porosity. In this reason, there has been a growing interest in electrospinning using chitosan in order to improve similarities to natural tissue. This article reviews the recent and relevant reports of the chitosan nanofibers fabricated by electrospinning and their biomedical applications.

참고문헌 (Reference)

1 S. Madduri, "Trophically and topographically functionalized silk fibroin nerve conduits for guided peripheral nerve regeneration" 31 : 2323-2334, 2010

2 Y. Zhang, "Three-dimensional macroporous calcium phosphate bioceramics with nested chitosan sponges for loadbearing bone implants" 61 : 1-8, 2002

3 Z. Q. Feng, "The effect of nanofibrous galactosylated chitosan scaffolds on the formation of rat primary hepatocyte aggregates and the maintenance of liver function" 30 : 2753-2763, 2009

4 Y. C. Wei, "The crosslinking of chitosan fibers" 30 : 2187-2193, 1992

5 Y. Zhang, "Synthesis and characterization of macroporous chitosan/calcium phosphate composite scaffolds for tissue engineering" 55 : 304-312, 2001

6 J. Berger, "Structure and interactions in chitosan hydrogels formed by complexation or aggregation for biomedical applications" 57 : 35-52, 2004

7 P. Sangsanoh, "Stability Improvement of Electrospun Chitosan Nanofibrous Membranes in Neutral or Weak Basic Aqueous Solutions" 7 : 2710-2714, 2006

8 R. Mincheva, "Preparation of Polyelectrolyte-Containing Nanofibers by Electrospinning in the Presence of a Non-Ionogenic Water-Soluble Polymer" 20 : 419-435, 2005

9 X. J. Huang, "Preparation and characterization of stable chitosan nanofibrous membrane for lipase immobilization" 43 : 3710-3718, 2007

10 H. Jiang, "Preparation and characterization of ibuprofen-loaded poly (lactide-co-glycolide)/poly (ethylene glycol)-g-chitosan electrospun membranes" 15 : 279-296, 2004

11 K. H. Jung, "Preparation and Antibacterial Activity of PET/Chitosan Nanofibrous Mats Using an Electrospinning Technique" 105 : 2816-2823, 2007

12 K. H. Jung, "Preparation and Antibacterial Activity of PET/Chitosan Nanofibrous Mats Using an Electrospinning Technique" 105 : 2816-2823, 2007

13 L. G. GRIFFITH, "POLYMERIC BIOMATERIALS" 48 : 263-277, 2000

14 J. Jin, "Novel Chitosan-Based Films Cross-Linked by Genipin with Improved Physical Properties" 5 : 162-168, 2004

15 I. O. Smith, "Nanostructured polymer scaffolds for tissue engineering and regenerative medicine" 1 : 226-236, 2009

16 J. Du, "Nanofibrous membranes from aqueous electrospinning of carboxymethyl chitosan" 19 : 125707-, 2008

17 J. Du, "Nanofibrous membranes from aqueous electrospinning of carboxymethyl chitosan" 19 : 125707-, 2008

18 K. Desai, "Nanofibrous chitosan non-wovens for filtration applications" 50 : 3661-3669, 2009

19 Z. Chen, "Intermolecular interactions in electrospun collagen-chitosan complex nanofibers" 72 : 410-418, 2008

20 Z. Chen, "Intermolecular interactions in electrospun collagen-chitosan complex nanofibers" 72 : 410-418, 2008

21 C. D. Sims, "Injectable Cartilage Using Polyethylene Oxide Polymer Substrates" 98 : 843-850, 1996

22 W. Wang, "Influences of mechanical properties and permeability on chitosan nano/microfibermesh tubes as a scaffold for nerve regeneration" 84A : 557-566, 2008

23 C. Kriegel, "Influence of Surfactant Type and Concentration on Electrospinning of Chitosan-Poly (Ethylene Oxide) Blend Nanofibers" 4 : 213-228, 2009

24 E. Guibal, "Heterogeneous catalysis on chitosan-based materials : a review" 30 : 71-109, 2005

25 J. L. Vondran, "Fabrication, optimization, and characterization of carboxymethylated chitosan nanofiber mats for cartilage regeneration applications" Drexel University 123-, 2007

26 S. S. Ojha, "Fabrication and Characterization of Electrospun Chitosan Nanofibers Formed via Templating with Polyethylene Oxide" 9 : 2523-2529, 2008

27 W. Wang, "Enhanced nerve regeneration through a bilayered chitosan tube: the effect of introduction of glycine spacer into the CYIGSR sequence" 85A : 919-928, 2008

28 R. Casarano, "Enhanced fibroblast adhesion and proliferation on electrospun fibers obtained from poly (isosorbide succinate-b-L-lactide) block copolymers" 50 : 6218-6227, 2009

29 X. Mo, "Electrospun nanofibers of collagen-chitosan and P(LLA-CL) for tissue engineering" 1 : 20-23, 2007

30 M. Ignatova, "Electrospun nano-fibre mats with antibacterial properties from quaternised chitosan and poly (vinyl alcohol)" 341 : 2098-2107, 2006

31 H. R. Jung, "Electrospun hydrophilic fumed silica/polyacrylonitrile nanofiber-based composite electrolyte membranes" 54 : 3630-3637, 2009

32 N. Bhattarai, "Electrospun chitosan-based nanofibers and their cellular compatibility" 26 : 6176-6184, 2005

33 F. CHEN, "Electrospun chitosan-P(LLA-CL) nanofibers for biomimetic extracellular matrix" 19 : 677-691, 2008

34 Z. Chen, "Electrospinning of collagenchitosan complex" 61 : 3490-3494, 2007

35 C. Kriegel, "Electrospinning of chitosan-poly (ethylene oxide) blend nanofibers in the presence of micellar surfactant solutions" 50 : 189-200, 2009

36 B. Duan, "Electrospinning of chitosan solutions in acetic acid with poly(ethylene oxide)" 15 : 797-811, 2004

37 S. D Vrieze, "Electrospinning of chitosan nanofibrous structures: feasibility study" 42 : 8029-8034, 2007

38 X. Geng, "Electrospinning of chitosan dissolved in concentrated acetic acid solution" 26 : 5427-5432, 2005

39 Y. Zhou, "Electrospinning of Chitosan/Poly(vinyl alcohol)/Acrylic Acid Aqueous Solutions" 102 : 5692-5697, 2006

40 K. Ohkawa, "Electrospinning of Chitosan" 25 : 1600-1605, 2004

41 F. Yoshiia, "Electron beam crosslinked PEO and PEO/PVA hydrogels for wound dressing" 55 : 133-138, 1999

42 K. Yagi, "Effectiveness of fructose-modified chitosan as a scaffold for hepatocyte attachment" 20 : 1290-1294, 1997

43 W. H. Park, "Effect of chitosan on morphology and conformation of electrospun silk fibroin nanofibers" 45 : 7151-7157, 2004

44 B. S. Kim, "Development of biocompatible synthetic extracellular matrices for tissue engineering" 16 : 224-, 1998

45 F. S. Ligler, "Development of Uniform Chitosan Thin-Film Layers on Silicon Chips" 17 (17): 5082-5084, 2001

46 S. Torres-Giner, "Development of Active Antimicrobial Fiber Based Chitosan Polysaccharide Nanostructures using Electrospinning" 8 : 303-314, 2008

47 J. D. Schiffman, "Cross-Linking Chitosan Nanofibers" 8 : 594-601, 2007

48 R. R. Klossner, "Correlation of Chitosan's Rheological Properties and Its Ability to Electrospin" 9 : 2947-2953, 2008

49 S. V. Fridrikh, "Controlling the fiber diameter during electrospinning" 90 : 144502-, 2003

50 C. L. Schauer, "Color changes in chitosan and poly (allyl amine) films upon metal binding" 434 : 250-257, 2003

51 K. Aiedeh, "Chitosan microcapsules as controlled release systems for insulin" 14 : 567-576, 1997

52 L. Li, "Chitosan bicomponent nanofibers and nanoporous fibers" 341 : 374-381, 2006

53 S. Hirano, "Chitosan as an ingredient for domesticanimal feeds" 38 : 1214-1217, 1990

54 Y. Z. Zhang, "Chitosan Nanofibers from an Easily Electrospinnable UHMWPEO-Doped Chitosan Solution System" 9 : 136-141, 2008

55 E. R. Welsh, "Chitosan Cross-Linking with a Water-Soluble, Blocked Diisocyanate. 1. Solid State" 3 : 1370-1374, 2002

56 C. K. S. Pillai, "Chitin and chitosan polymers: Chemistry, solubility and fiber formation" 34 : 641-678, 2009

57 B. M. Min, "Chitin and chitosan nanofibers: electrospinning of chitin and deacetylation of chitin nanofibers" 45 : 7137-7142, 2004

58 G. Kunike, "Chitin and chitosan" 42 : 318-342, 1927

59 S. W. Ko, "Chitin (or Chitosan) Blends and Their Applications" 8 : 538-545, 1997

60 S. Torres-Giner, "Characterization of the morphology and thermal properties of Zein Prolamine nanostructures obtained by electrospinning" 22 : 601-614, 2008

61 H. Matsumoto, "Characterization of chitosan nanofiber fabric by electrospray deposition: Electrokinetic and adsorption behavior" 310 : 678-681, 2007

62 M. Hasegawa, "Characterization of cellulose-chitosan blend films" 45 : 1873-1879, 1992

63 Y. Zhang, "Calcium phosphate/chitosan composite scaffolds for controlled in vitro antibiotic drug release" 62 : 378-386, 2002

64 X. Li, "Biological Activity of Chitosan-Sugar Hybrids: Specific Interaction with Lectin" 11 : 176-179, 2000

65 R. Mincheva, "Bicomponent aligned nanofibers of N-carboxyethylchitosan and poly (vinyl alcohol)" 43 : 2809-2818, 2007

66 K. MNVR, "A review of chitin and chitosan applications" 46 : 1-27, 2000

67 B. Duan, "A nanofibrous composite membrane of PLGA-chitosan/PVA prepared by electrospinning" 42 : 2013-2022, 2006