양극성 장애에서 발병 연령에 따른 증상 및 예후의 차이 : 전향적 1년 추적 연구 = Clinical Features and Prognosis Related to Age at Onset in Bipolar Disorder : A Prospective 1 Year Follow-Up

다국어 초록 (Multilingual Abstract)

Objectives : There have been several studies demonstrating that age at onset is associated with clinical and functional outcome in bipolar disorder. The purpose ofthis study was to investigate whether age at onset would influence on the prognosis of patients with bipolar I disorder in a Korean sample.
Methods : Thirty-one patients with bipolar I disorder (DSM-IV) were recruited. Age at onset was split at age 30 years into early onset (n=15) and late onset (n=16) groups. These patients were followed at 1 year to assess re-hospitalization, Psychiatric symptoms (Brief Psychiathc Rating Scale, Young Mania Rating Scale), and social functioning (Korean version of the Social Adjustment Scale II revised version : KSAS II-RV). The subgroups were compared by Mann-Whitney U test and chi-square test.
Results : Early onset group had more psychotic symptoms at hospitalization (χ²=5.743, P=.029) and had more KSAS II-RV score aRer 1 year (U=49.000, P=.004). Other psychiatric symptoms except psychosis were not significantly different bet-ween early onset and late onset group. KSAS II-RV score was not significantly correlated with BPRS and YMRS score.
Conclusion : Our data suggest that early onset group may have poorer social functioning than late onset group in bipolar I disorder.