This study was attempted to investigate the effect of Gardeniae Fructus on GOT, GPT, Al.p, LDH activities and level of total cholesterol in serum of CCl₄, and D-galactosamine intoxicated rats, and bile excretion. The geniposide and extract caused ...
This study was attempted to investigate the effect of Gardeniae Fructus on GOT, GPT, Al.p, LDH activities and level of total cholesterol in serum of CCl₄, and D-galactosamine intoxicated rats, and bile excretion. The geniposide and extract caused a remarkable decrease of GPT activities, level of total cholesterol in serum of CCl₄ intoxicated rats at EtOH Ex. 300, 500 ㎎/㎏ p.o., MeOH Ex. and geniposide 100 ㎎/㎏ p.o., and. GOT, Al.p activities were significantly decreased compared with control group. It caused a remarkable decrease of GPT., Al.p, LDH activities in serum of n-galactosamine intoxicated rats, and GOT activities was significantly decreased compared with control group. The geniposide and extract caused a remarkable increase of bile excretion, when administration of EtOH extract 500 ㎎/㎏ p.o., MeOH extract 100 ㎎/㎏ i.d., MeOH extract 50 ㎎ and geniposide 50 ㎎/㎏ i.v. compared with normal-control group.