Treatment Patterns and Persistence Among Patients Newly Diagnosed With Migraine in South Korea: A Retrospective Analysis of Health Claims Data|RISS 상세보기

다국어 초록 (Multilingual Abstract)

Background and Purpose Migraine is one of the most common chronic neurological diseases worldwide. Although diverse treatment regimens have been recommended, there is insufficient evidence for which treatment patterns to apply in routine clinical settings.
Methods We used nationwide claims data from South Korea for 2015–2021 to identify incident migraine patients with at least one prescription for migraine. Patients were categorized according to their initial treatment classes and followed up from the date of treatment initiation. Treatment regimens included prophylactic treatments (antidepressants, anticonvulsants, beta blockers, calcium-channel blockers, and renin-angiotensin-aldosterone system [RAAS] inhibitors) and acute treatments (acetaminophen, antiemetics, aspirin, ergotamine, nonsteroidal anti-inflammatory drugs [NSAIDs], opioids, and triptans). The treatment patterns of migraine were evaluated until the end of the study period, including the secular trends, prevalence, persistence, and changes in migraine treatment.
Results Among the 761,350 included patients who received migraine treatment, the most frequently prescribed acute treatment was an NSAID (69.9%), followed by acetaminophen (50.0%). The most-prescribed prophylactic treatment was flunarizine (36.9%), followed by propranolol (24.4%). Among the patients, 54.8% received acute treatment, 13.5% received prophylactic treatment, and 31.6% received both treatment types. However, 65.7% of the patients discontinued their treatment within 3 months. The 3-month persistence rate was highest for triptans (25.2%) among the acute treatments and for RAAS inhibitors (62.0%) among the prophylactic treatments.
Conclusions While the prevalence rates of medication use were found to align with current migraine guidelines, frequent switching and rapid discontinuation of drugs were observed in routine clinical settings.

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참고문헌 (Reference)

1 Orlando V, "Treatment patterns and medication adherence among newly diagnosed patients with migraine : a drug utilisation study" 10 : e038972-, 2020

2 Meyers JL, "Treatment patterns and characteristics of patients with migraine in Japan : a retrospective analysis of health insurance claims data" 39 : 1518-1534, 2019

3 Wang YF, "Treatment pattern and health care resource utilization for Taiwanese patients with migraine : a population-based study" 14 : 1222912-, 2023

4 Korean Headache Society, "Treatment guideline of pharmacological preventive therapy for episodic migraine" Medical Publisher 2019

5 Ailani J, "The American Headache Society consensus statement : update on integrating new migraine treatments into clinical practice" 61 : 1021-1039, 2021

6 Lipton RB, "Stratified care vs step care strategies for migraine : the disability in strategies of care(DISC)study : a randomized trial" 284 : 2599-2605, 2000

7 Lipton RB, "Rimegepant, an oral calcitonin gene-related peptide receptor antagonist, for migraine" 381 : 142-149, 2019

8 Kim KM, "Prevalence, disability, and management patterns of migraine in Korea : nationwide survey data from 2009 and 2018" 17 : 77-85, 2021

9 Silberstein SD, "Practice parameter : evidence-based guidelines for migraine headache(an evidence-based review) : report of the Quality Standards Subcommittee of the American Academy of Neurology" 55 : 754-762, 2000

10 Hepp Z, "Persistence and switching patterns of oral migraine prophylactic medications among patients with chronic migraine : a retrospective claims analysis" 37 : 470-485, 2017