Glucocorticoid가 비장세포 임파구의 증식,Interleukin-2(IL-2) 생산 및 말초 혈액 임파구의 IL-2수용체 발현에 미치는 영향 = Effects of glucocorticoid on proliferation,production of interleukin 2(IL-2) and on expression of IL-2 receptors in lymphocytes

다국어 초록 (Multilingual Abstract)

Glucocorticoids are widely used as therapeutic agents in as variety of allergic and inflammatory diseases and in transplantation rejection. Although glucocorticoids are thought to influence on the immunologic reation, they are not fully known to influence on the immune cell function. In this report, we have studies effects of glucocorticoid. dexamethasone, on porliferation and production of interleukin-2(IL-2) in mouse splenic lymphocytes and on expression of IL-2 production, we isolated C57BL6 mice splenic cells and stimulated with Con-A(5㎍/ml). As the concentration of dexamethasone was increased, the proliferation and the IL-2 production of mouse splenic lymphocytes stimulated by Con-A (5㎍/ml) were decreased. And the expression of IL-2 receptors in human peripheral blood lymphocytes was also decreased in addition of dexamethasone.
These findings suggest that proliferation, IL-2 production, and IL-2 receptor expression of immune cells are inhibited by glucocorticoid, dexamethasone.