골조직공학에서의 생체재료 지지체의 적용과 혈관생성 = Updates on Scaffold Application and Vascularization in Bone Tissue Engineering

국문 초록 (Abstract)

골조직공학은 지지체를 이용한 골결손의 치유와 재생을 목적으로 생분해성 지지체에 골형성
세포 (osteogenic cells)를 이식하는 다양한 기술을 근간으로 한다. 본 총설에는 지지체의 재료 개발의 관점
과 신생혈관생성의 관점에서 골조직공학의 발전에 대한 최신지견을 소개하고자 한다. 우선, 골조직공학
의 원리 및 생체재료의 주요 구성성분 그리고 조직공학적 골형태의 지지체 제작에 사용된 새로운 재료의
개발(합성폴리머와 칼슘인산염의 혼합체 등)에 대해서 소개하고 이들 재료의 다공성, 기공의 크기, 상
호결합성, 기공벽의 세부구조 등의 평가를 통해 이들의 장점과 한계에 대하여 논의하고자 한다. 또한 실
험실의 결과를 성공적으로 임상에 적용하기 위하여는, 미세혈류(microcirculation)의 유도가 필수적인데
본고에서는 골조직공학에서의 혈관망(vascular network)의 중요성에 대하여 논의하고 최근 연구되고 있
는 혈관형성의 촉진 방법을 소개하고자 한다.

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