發癌에 대한 미량원소의 기능에 관한 고찰

다국어 초록 (Multilingual Abstract)

Trace elements play important roles in the growth and development not only of normal but also of malignant cells. Due to the metabolic differences between healthy and cancerous tissues it may be possible to control or even inhibit tumor growth by altering the supply of trace elements in the organism as a whole. The trace element status of postoperative cancer patients should also be considered in order to minimize the chance of recurrences.
Their diets should be closely monitored for trace elements that are known to stimulate tumor growth.
Cancer prevention programs should not only aim at lowering the human exposure to environmental carcinogens but should also contain guidelines that will assure that the organism is maintained in a state of maxial cancer resistance.
The purpose of this study is to examine of the function of trace elements in carcinogenesis.
The results are summarized as follows :
1. Selenium : Statistically significant inverse associations of apparent dietary selenium intakes were observed with the age-corrected mortalities from leukemia and cancers of the intestine, rectum, breast, ovary, prostate, lung, pancreas, skin, bladder.
2. Arsenic : The deleterious effects of arsenic seem to be confined to higher concentrations. At low levels, arsenic is essential for the maintenance of health.
3. Iodine : Iodine deficiency enhances sus-ceptibility to cancer.
4. Zinc : Large doses of zinc reduce symptoms of selenium toxicity and accumulates in spontaneous mammary carcinoma.
5. Cadmium : Direct correlations was reported between cadmium concentration of supply waters with mortality from cancers of the colon, esophagus, mouth, larynx and lung.
6. Lead : Experimental studies with animals has produced renal carcinomas through injection of lead phosphate and cancers has also been induced following oral or parenteral administration of lead phosphate, lead acetate or lead subacetate.
7. Nickel : Nickel is one of the most widely studied metal carcinogens and has been shown to be responsible for occupational cancers of the lung and nasal cavities.
8. Chromium : Chromium has a weakly inhibitory effect on tumorigenesis only at relatively high parenteral dosage lvels Ce.g., 30 ppm in the water supply).
9. Copper : Elevated copper concentrations has been observed in patients with certain malignant diseases : Hodgkin ‘s disease, sarcoma in lung and breast, cervical and other gynecological cancers, and occasionally in cancer of the bladder and larynx.
Under special experimental conditions, copper salts were found to have anticarcinogenic properties.
10. Manganese : Manganese accumulates in malignant breast tissue aS'well as in osteogenic sarcoma. Its compounds may thus act as potential cocarcino genic factors.
11. Mercury : Mercury poses the selenium-antagonistic effects
12. Iron : Occupational exposure to certain iron ores is believed to increase lung cancer risk. The subcutaneous administration of iron dextran complexes has produced fibrosarcomas in animal experiments.

목차 (Table of Contents)

• Ⅰ. 서론 1
• Ⅱ. 본론 2
• 1. Inorganic Carcinogens 와 Anticarcinogens 2
• 2. Trace Elements 5
• 1) Selenium 5
• ① Anticarcinogenic Action의 Mechanisms 7
• ② Dietary Selenium Intakes 9
• 2) Arsenic 10
• 3) Iodine 12
• 4) Zinc 12
• 5) cadmium 14
• 6) Lead 15
• 7) Nickel 15
• 8) Chromium 15
• 9) Copper 16
• 10) Manganese 17
• 11) Mercury 18
• 12) Iron 19
• Ⅲ. 결론 19