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ScienceON<P>Reactive oxygen species (ROS), generated by ionizing radiation, has been implicated in its effect on living tissues. We confirmed the changes in the oxidative stress markers upon irradiation. We characterized the changes in the proteome profi...
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RISS 인기검색어
https://www.riss.kr/link?id=A107687626
-
저자
Park*, Eui‐ ; Chul ; Yoon, Jong‐ ; Bok ; Seong*, Jin‐ ; Sil ; Choi, Kyoung‐ ; Soo ; Kong, Eung‐ ; Sik ; Kim, Yun‐ ; Jeong ; Park, Young‐ ; Mee ; Park, Eun‐ ; Mi
- 발행기관
- 학술지명
- 권호사항
-
발행연도
2006
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작성언어
-
- 주제어
-
등재정보
SCOPUS,SCIE
-
자료형태
학술저널
-
수록면
19-35(17쪽)
- 제공처
-
0
상세조회 -
0
다운로드
부가정보
다국어 초록 (Multilingual Abstract)
<P>Reactive oxygen species (ROS), generated by ionizing radiation, has been implicated in its effect on living tissues. We confirmed the changes in the oxidative stress markers upon irradiation. We characterized the changes in the proteome profile in rat liver after administering irradiation, and the affected proteins were identified by MALDI-TOF-MS and ESI-MS/MS. The identified proteins represent diverse sets of proteins participating in the cellular metabolism. Our results demonstrated that proteomics analysis is a useful method for characterization of a global proteome change caused by ionizing radiation to unravel the molecular mechanisms involved in the cellular responses to ionizing radiation.</P>
<P>Reactive oxygen species (ROS), generated by ionizing radiation, has been implicated in its effect on living tissues. We confirmed the changes in the oxidative stress markers upon irradiation. We characterized the changes in the proteome profile in rat liver after administering irradiation, and the affected proteins were identified by MALDI-TOF-MS and ESI-MS/MS. The identified proteins represent diverse sets of proteins participating in the cellular metabolism. Our results demonstrated that proteomics analysis is a useful method for characterization of a global proteome change caused by ionizing radiation to unravel the molecular mechanisms involved in the cellular responses to ionizing radiation.</P>
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