UVB 조사 후 라벤더 오일의 IL-10 생성에 미치는 효과 = The Effect of Lavender Essential Oil(Lavandular officinalis Chaix.) to theproduction of Interleukin-10 after UVB-irradiatiation

다국어 초록 (Multilingual Abstract)

In order to determine the effect of lavender(Lavandular officinalis Chaix)oil on the skin immunity and skin injury, we examined the effect of lavender oil of IL-10 production in the UVB irradiated mice and CCD-986sk cells. In vitro experiments, Lavender oils at concentrations 0.01, 0.1 and 1% were affected to the production of IL-10 in the CCD-986 sk (2.105 cells/well) cell. When UVB-irradiatedCCD-986sk cells was treated lavender oil, the production of IL-10 was gradually reduced in a time-dependent manner. Amount of IL-10produced in control and 0.1% treated of lavender oil group were 9.03.1.43 and 7.66.0.04 pg/mg protein 6 houres after UVB-irradiation, respectively. In vivo experiments, the treated group with twice a day of lavender oil after of UVB-irradiation were reduced the production of IL-10 more than UVB-irradiated group. In light micrograph, the treated group with twice a day of lavender oil after of UVB-irradiation inhibited the proliferation of the epidermis at the 7day, 15day, and 21 day groups more than UVB-irradiated group. These results suggest that lavender oil has immune stimulating effects and reduce flammation on UVB-irradiated mice skins and cells. Therefore, lavender oil might be used as a potential resource for therapy of UVB-irradiated skin damage.