The fabrication of a nano-porous polyoxazoline stamp tip for scanning probe nanolithography has been reported, and the patterning of nanometer scale high-molecular weight proteins at ultra-fast speed demonstrated using the stamp tip. A nanoporous poly...
The fabrication of a nano-porous polyoxazoline stamp tip for scanning probe nanolithography has been reported, and the patterning of nanometer scale high-molecular weight proteins at ultra-fast speed demonstrated using the stamp tip. A nanoporous polymer-coated silicon tip was constructed using ring opening polymerization of 2-methyl-2-oxazoline on the surface of the tip employing a simple solution polymerization method. Because polyoxazoline is a hydrophilic and biocompatible polymer, these tips can easily absorb and release water-based biomolecules via their pores. Using dip-pen nanolithography, the patterning of Human IgG and PSA proteins using these stamp tips has been demonstrated. The results showed that protein nano-patterns can be generated at least five times
faster with this method than with a conventional silicon tip.