마이크로채널 내 이중유화 액적 형성을 통한 마이크로캡슐 제조 = Fabrication of Polymeric Microcapsules in a Microchannel using Formation of Double Emulsion

다국어 초록 (Multilingual Abstract)

In this study, we present simple microfluidic approach for the synthesis of monodisperse microcapsules by using droplet-based system. We generate double emulsion through single step in the microfluidic device having single junction while conventional approaches are limited in surface treatment for the generation of double emulsion. First, we have injected disperse fluid containing FC-77 oil and photocurable ethoxylated trimethylolpropane triacrylate (ETPTA) and water containing 3 wt% poly(vinyl alcohol) (PVA) as continuous phase into microfluidic device. Under the condition, we easily generate double emulsion with high monodispersity by using flow focusing. The double emulsion droplets are transformed into microcapsules under the UV irradiation via photopolymerization. In addition, we control thickness of double emulsion`s shell by controlling flow rate of ETPTA. We also show that the size of double emulsions can be controlled by manipulation of flow rate of continuous phase. Furthermore, we synthesize microcapsules encapsulating various materials for the application of drug delivery systems.

참고문헌 (Reference)

1 정재훈, "액적 기반의 미세유체 시스템의 현황" 한국화학공학회 48 (48): 545-555, 2010

2 강성민, "미세채널에서 수력학적 조절을 통한 단분산성 다중 액적 생성" 한국화학공학회 50 (50): 733-737, 2012

3 황소라, "미세유체를 이용한 단분산성 이중 에멀젼 생성 방법" 한국고분자학회 36 (36): 177-181, 2012

4 Hennequin, Y., "Synthesizing Microcapsules with Controlled Geometrical and Mechanical Properties with Microfluidic Double Emulsion Technology" 25 (25): 7857-7861, 2009

5 Yoshida, K., "Stability of Vitamin A in Oil-in-water-in-oil-type Multiple Emulsions" 76 (76): 195-200, 1999

6 Deng, N. N., "Simple and Cheap Microfluidic Devices for the Preparation of Monodisperse Emulsions" 11 (11): 3963-3969, 2011

7 황소라, "Regioselective Surface Modification of PDMS Microfluidic Device for the Generation of Monodisperse Double Emulsions" 한국고분자학회 20 (20): 422-428, 2012

8 Esser-Kahn, A. P., "Programmable Microcapsules from Self-Immolative Polymers" 132 (132): 10266-10268, 2010

9 Bonilla, E., "Predicting Suitable Storage Conditions for Spray-dried Microcapsules Formed with Different Biopolymer Matrices" 24 (24): 633-640, 2010

10 Freiberg, S., "Polymer Microspheres for Controlled Drug Release" 282 (282): 1-18, 2004

11 Karapanagiotis, I., "Polymer Film Rupturing in Comparison with Leveling and Dewetting" 594 (594): 192-202, 2005

12 최창형, "PEG 마이크로 섬유 제조를 위한 마이크로플루이딕 제조방법" 한국화학공학회 48 (48): 470-474, 2010

13 Utada, A. S., "Monodisperse Double Emulsions Generated from a Microcapillary Device" 308 (308): 537-541, 2005

14 Nisisako, T., "Microstructured Devices for Preparing Controlled Multiple Emulsions" 31 (31): 1091-1098, 2008

15 Choi, C. H., "Microfluidic Fabrication of Complex-shaped Microfibers by Liquid Template-aided Multiphase Microflow" 11 (11): 1477-1483, 2011

16 Elsoda, M., "Microencapsulated Enzyme-Systems for the Acceleration of Cheese Ripening" 6 (6): 319-326, 1989

17 Kurayama, F., "Microcapsule with a Heterogeneous Catalyst for the Methanolysis of Rapeseed Oil" 135 : 652-658, 2013

18 최창형, "In Situ Microfluidic Synthesis of Monodisperse PEG Microspheres" 한국고분자학회 17 (17): 163-167, 2009

19 Bauer, W. A. C., "Hydrophilic PDMS Microchannels for High-throughput Formation of Oil-in-water Microdroplets and Water-in-oil-in-water Double Emulsions" 10 (10): 1814-1819, 2010

20 Abate, A. R., "High-Order Multiple Emulsions Formed in Poly(dimethylsiloxane) Microfluidics" 5 (5): 2030-2032, 2009

21 Xu, S. Q., "Generation of Monodisperse Particles by Using Microfluidics: Control over Size, Shape, and Composition" 44 (44): 724-728, 2005

22 Choi, C. H., "Generation of Monodisperse Alginate Microbeads and in situ Encapsulation of Cell in Microfluidic Device" 9 (9): 855-862, 2007

23 Anna, S. L., "Formation of Dispersions Using “Flow Focusing” in Microchannels" 364-366, 2003

24 정재훈, "Efficient In situ Production of Monodisperse Polyurethane Microbeads in Microfluidic Device using Increase of Residence Time of Droplets" 한국바이오칩학회 3 (3): 44-49, 2009

25 Chen, P. W., "Designer Polymer- Based Microcapsules Made Using Microfluidics" 28 (28): 144-152, 2012

26 Harry, R. A., "Contemporary Polymer Chemistry. 3rd ed." Prentice Hall 2003

27 Vasiljevic, D., "An Investigation into the Characteristics and Drug Release Properties of Multiple W/O/W Emulsion Systems Containing Low Concentration of Lipophilic Polymeric Emulsifier" 309 (309): 171-177, 2006

28 Kim, S. H., "Amphiphilic Crescent-Moon-Shaped Microparticles Formed by Selective Adsorption of Colloids" 133 (133): 5516-5524, 2011

29 Ichikawa, H., "A Novel Positively Thermosensitive Controlled-release Microcapsule with Membrane of Nano-sized Poly(N-isopropylacrylamide) Gel Dispersed in Ethylcellulose Matrix" 63 (63): 107-119, 2000