饑餓狀態가 腦의 構成成分 및 放射性醋酸의 編入에 미치는 影響 = Effect of Starvation on Composition of Brain Tissue and Incorporation of Acetate-¹⁴C

국문 초록 (Abstract)

饑餓狀態가 動物에 腦重量, 腦重量對 體重比率, 腦의 主要構成成分인 腦質 및 蛋白質의 量과 이들의 合成速度에 어떠한 影響을 미치는가를 調査해 보기 위하여 體重이 300g前後로 成長한 흰쥐를 正常攝食群과 24時間 絶食群으로 나누어 調査해 본 結果는 다음과 같다.
正常 成熱쥐의 腦重量은 平均 1.27g로서 體重과의 比率은 0.42%이었다. 그리고 腦의 脂質量은 50.7㎎/g, 蛋白質量은 104.1㎎/g이었으며, 이들의 比率은 0.49로서 腦에는 蛋白質이 2倍나 많이 含有되어 있었다. 이것에 對하여 絶食群의 腦重量, 腦重量對 體重比率, 腦의 脂質 및 蛋白質등은 正常攝食群의 그것과 比較해서 有異한 差異는 없었다. 그리고 放射性 醋酸의 腦의 脂質 및 蛋白質에의 編入樣相은 肝이나 血淸에서의 그것과는 달리 적은 量이 時間經過에 따라 완만하게 編入되었으며, 이러한 編入樣相은 絶食群에서도 비슷하였다. 特히 蛋白質에의 編入量은 絶食群에서 약간 增加된 傾向이었으나 有意한 것은 아니었다.
以上의 結果로 보아 腦의 主要 構成成分은 營養環境에 크게 影響을 받지 않고 安定性을 維持한다고 하겠으며, 또한 이들 物質의 代謝回轉도 別다른 變動이 없다고 하겠다.

다국어 초록 (Multilingual Abstract)

Effects of starvation on brain weight, brain/body weight ration content of lipid and protein and rate of synthesis were studied in Sprague-Dawley rat weighing 300 gm in normal feeding state and 24hr starvatioin state.
Brain weight of normal adult rat was 1.27 gm and its ratio to body was 0.42%. And brain lipid coontent was 50.7 mglgm tissue and protein content was 104.1mg/gm tissue. Lipid/protein ratio was 0.49, revealed 2 times more lipid in brain. Onn the otherhand, brain weight, brain/body weight ratio, brain lipid and protein content in starved group did not reveal significant difference.
The incorporation of radioactive acetic acid into brain lipid and protein was very small amount and slow comparing to their incorporation into liver and this pattern of incorporation was same in starved group. but was was not statistically significant.
These results are coompatibvle with the view that composition of brain was not significantly affected by nutritional condition and show very stable condition and metabolic conversion of foodstuff did not change significantly.