양극성 장애 환자와 정상인에서 계절성의 양상과 관련 요인 탐색 = Seasonal Changes in Mood and Behavior and Associated Factors of Seasonality in Korean Bipolar Disorder Patients and Normal Controls

다국어 초록 (Multilingual Abstract)

Objectives : Recurrence of mood episodes associated with a specific season has been described in various mood disorders. Seasonal change in mood and behavior as a lifetime trait is also observed in healthy individuals. This study aimed at comparing the lifetime trait of seasonal variations of mood and behavior between bipolar disorder patients and controls as well as investigating associated factors of seasonality. Methods : Subjects were ninety-four clinically stable patients with bipolar disorder and 188 age- and sex-matched healthy controls. Seasonality of mood and behavior was assessed retrospectively on lifetime basis using Seasonal Pattern Assessment Questionnaire(SPAQ). Results : The patient group showed a higher median global seasonality score(GSS) of SPAQ and a higher rate of seasonal affective disorder(SAD) compared to the control group(p < 0.0001). For subjects showing prominent seasonality, the seasonal symptom profile and seasonal pattern was similar in both patient and control groups. In addition to the diagnosis, female gender was shown to be a predictor of seasonality in the multiple linear regression analysis(p = 0.045). Conclusion : This study suggests that lifetime trait of seasonality may be related to the susceptibility of bipolar disorder.

참고문헌 (Reference)

1 백지현, "양극성 장애에서 1형과 2형 환자 간의 임상 양상 비교" 대한신경정신의학회 48 (48): 232-239, 2009

2 Kaplan Z, "Violence in hospitalized psychiatric patients: diurnal and seasonal patterns" 60 : 199-204, 1996

3 Marangell LB, "The functional impact of subsyndromal depressive symptoms in bipolar disorder: data from STEP-BD" 114 : 58-67, 2009

4 Magnusson A, "The diagnosis, symptomatology, and epidemiology of seasonal affective disorder" 10 : 625-634, 2005

5 Portella AT, "The association between seasonal and premenstrual symptoms is continuous and is not fully accounted for by depressive symptoms" 194 : 833-837, 2006

6 Murray G, "The Seasonal Pattern Assessment Questionnaire as a measure of mood seasonality: a prospective validation study" 120 : 53-59, 2003

7 Han L, "Summer and winter patterns of seasonality in Chinese college students: a replication" 41 : 57-62, 2000

8 Fava GA, "Subclinical symptoms in mood disorders: pathophysiological and therapeutic implications" 29 : 47-61, 1999

9 Kasper S, "Seasonality in major depressed inpatients" 19 : 243-248, 1990

10 Shin K, "Seasonality in a community sample of bipolar, unipolar and control subjects" 86 : 19-25, 2005

11 Praschak-Rieder N, "Seasonal variation in human brain serotonin transporter binding" 65 : 1072-1078, 2008

12 Blehar MC, "Seasonal mood disorders: consensus and controversy" 26 : 465-494, 1990

13 Hakkarainen R, "Seasonal changes, sleep length and circadian preference among twins with bipolar disorder" 3 : 6-, 2003

14 Madden PA, "Seasonal changes in mood and behavior. The role of genetic factors" 53 : 47-55, 1996

15 Rosenthal NE, "Seasonal affective disorder in A description of the syndrome and preliminary findings with light therapy" 41 : 72-80, 1984

16 Thompson C, "Seasonal affective disorder and season-dependent abnormalities of melatonin suppression by light" 336 : 703-706, 1990

17 Kim SJ, "Seasonal Variations of Mood and Behavior in Korean Medical Students" 11 : 95-99, 2004

18 Lee MS, "Seasonal Variations in Mood and Behavior in Korean High School Students" 12 : 111-116, 2005

19 Rosenthal NE, "Seasonal Pattern Assessment Questionnaire in National Institute of Mental Health" Washington, DC 1987

20 Ozaki N, "Rosenthal NE. Prevalence of seasonal difficulties in mood and behavior among Japanese civil servants" 152 : 1225-1227, 1995

21 Rosenthal NE, "Role of serotonin transporter promoter repeat length polymorphism(5-HTTLPR) in seasonality and seasonal affective disorder" 3 : 175-177, 1998

22 Bauer M, "Relationship among latitude, climate, season and self-reported mood in bipolar disorder" 116 : 152-157, 2009

23 Steinhausen HC, "Prevalence of self-reported seasonal affective disorders and the validity of the seasonal pattern assessment questionnaire in young adults Findings from a Swiss community study" 115 : 347-354, 2009

24 Benazzi F, "Prevalence and clinical correlates of residual depressive symptoms in bipolar II disorder" 70 : 232-238, 2001

25 Karadag F, "Menstrually related symptom changes in women with treatment-responsive bipolar disorder" 6 : 253-259, 2004

26 Young MA, "Measuring seasonality: psychometric properties of the Seasonal Pattern Assessment Questionnaire and the Inventory for Seasonal Variation" 117 : 75-83, 2003

27 Sayer HK, "Mania and seasonality in the southern hemisphere" 23 : 151-156, 1991

28 Schaffer A, "Influence of season and latitude in a community sample of subjects with bipolar disorder" 48 : 277-280, 2003

29 Jang KL, "Gender differences in the heritability of seasonal mood change" 70 : 145-154, 1997

30 Hardin TA, "Evaluation of seasonality in six clinical populations and two normal populations" 25 : 75-87, 1991

31 Kasper S, "Epidemiological findings of seasonal changes in mood and behavior in A telephone survey of Montgomery County, Maryland" 46 : 823-833, 1989

32 Lee HJ, "Effects of season and climate on the first manic episode of bipolar affective disorder in Korea" 113 : 151-159, 2002

33 Correll CU, "Early identification and high-risk strategies for bipolar disorder" 9 : 324-338, 2007

34 APA, "Diagnostic and Statistical Manual of Mental Disorders, 4th edition American Psychiatric Association" Washington, DC 1994

35 Hendrick V, "Course of psychiatric disorders across the menstrual cycle" 4 : 200-207, 1996

36 Guy W, "Clinical global impressions in Editor, ECDEU assessment manual for psychopharmacology (Revised)" National Institute of Mental Health, Rockville 217-221, 1976

37 Jain S, "Climate and admissions for mania in the tropics" 26 : 247-250, 1992

38 Wehr TA, "Circadian rhythm disturbances in manic-depressive illness" 42 : 2809-2814, 1983

39 Thompson C, "A comparison of normal, bipolar and seasonal affective disorder subjects using the Seasonal Pattern Assessment Questionnaire" 14 : 257-264, 1988