Trasylol 및 Dexamethasone 이 토끼의 지주막하 출혈후에 오는 뇌수종 발생에 미치는 영향 = Transylol and Dexamethasone Therapy for Hydrocephalus after Experimental Subarachnoid Hemorrhage

다국어 초록 (Multilingual Abstract)

Hydrocephalus was reported to occur in man in approximately 35% of subarachnoid hemorrhage add shunting procedure was inevitable in about one third of them.
This study was planned to explore the possibility of preventing the evolution of hydrocephalus after subarachnoid hemorrhage by Trasylol or dextmathasone therapy.
A total of eighty-seven rabbits weighing 3㎏ were used. Three times of cisternal injections of 0.15ml of blood were performed at every other day. Seventeen rabbits died of initial technical failure at the time of the first cisternal injection of blood. The remaining seventy rabbits were divided into four groups; Group Ⅰ (20 rabbits) was of control group, Group Ⅱ (10 rabbits) received three cisternal injection of 5,000 KIU of Trasylol at the time of cisternal blood injection, Group Ⅲ (20 rabbits) received intravenous injection of 2,000 KIU of Trasylol four times daily for 10 days, and Group Ⅳ (20 rabbits) was treated with intramuscular injection of dexamethasone which was gradually tapered for 10 days. All the rabbits were sacrified three weeks later the last cisternal injection of blood. Their heads were sectioned and ventricular measurement was made.
Trasylol and dexamethasone reduced the incidence of hydrocephalus from 31% to 43% while 81% in control group. The mortality rate after subarachnoid hemorrhage was also remarkably reduced in the treated groups.
A reduction in post-SAH hydrocephalus can be achieved by Trasylol and dexamethasone. It seems to be by their anti-inflammatory effects.