수용액에서 수정된 항암 전구약물과 단백질 간의 상호작용 = Interaction of Modified Anti-Cancer Prodrug and Protein in Aqueous Solution

다국어 초록 (Multilingual Abstract)

We have investigated the interaction of a new water-soluble paclitaxel (7-mPEG5,000-succinyloxymethyloxycarbonyl-paclitaxel, PP7) and hen egg albumin (Mr ~45,000) by pulse-gradient field NMR (PFG-NMR). Diffusion coefficient of PP7 with Albumin in modified Hank`s Balanced Salt Solution (MHBSS) was measured as a function of PP7 (0.0~1.7% w/w) and albumin (0.0~1.4% w/w) concentration at different temperatures. This study suggested that the results of molecular mobility and interaction can be used to determine the transport mechanisms in human body liquid.

참고문헌 (Reference)

1 Wani, M., 93 (93): 2325-2337, 1971

2 Heimann, R. B., 32 (32): 913-921, 2001

3 Gregory, R., 12 (12): 401-415, 1993

4 Hess, M., 201 (201): 163-170, 2003

5 Kingston, D. G. I., 52 (52): 1-34, 1991

6 Illum, L., 40 (40): 367-374, 1987

7 Mcpherson, T., 14 (14): 176-186, 1995

8 Vert, M., 11 (11): 1307-1317, 2000

9 Sheth, S., 94 (94): 8399-8404, 1997

10 Sung, C., 31 (31): 556-563, 1990

11 Lee, J. H., 23 (23): 351-368, 1989

12 Sohn, J. S., 9 (9): 85-94, 2005

13 Hess, M., 10 (10): 364-375, 2006

14 Ha, B. J., 7 (7): 59-66, 1996

15 Dreborg, S., 6 (6): 315-356, 1990

16 Yamaoka, T., 83 (83): 601-606, 1994

17 Brinkman, E., 11 (11): 200-205, 1990

18 Gombotz, W. R., 37 (37): 91-107, 1989

19 Cooper, S. L., "Polymer biomaterials in solutions, as interfaces and solids" VSP Utrecht 919-929, 1995

20 Cooper, S. L., "Polymer biomaterials in solutions, as interfaces and solids" VSP Utrecht 195-204, 1995

21 Powell, G. M., "Polyethylene glycol" McGraw-Hill 1831-, 1980

22 Bailey, J., "Poly(ethylene oxide)" Academic press 38-40, 1976

23 Harris, J. M., "Poly(ethylene glycol) chemistry" Plenum Press 29-55, 1992

24 Sohn, J. S., "Physicochemical properties of water soluble paclitaxel" Chosun University 2005

25 Bailey, Jr., F. E., "Alkylene oxides and their polymers" 214-215, 1991