영지다당체의 실험적 간경화에 대한 섬유화 억제효과에 대한 연구 = Studies on the Antifibrotic Effects of Polysaccharides from Ganoderma lucidum

다국어 초록 (Multilingual Abstract)

This study was carried out to investigate the effects of the water soluble fraction and the ethanol soluble fraction of polysaccharide extracted from Ganoderma lucidum. The experimental hepatic cirrhosis was induced by bile duct ligation/scission (BDL/S) in rats. BDL/S rats in each group were dosed 5 mg/rat/day of the ethanol soluble polysaccharide extracted from Ganoderma lucidum and were dosed 0.5, 2.0, 5.0 or 10 mg/rat/day of the water soluble polysaccharide orally for 4 weeks after the operation. Antifibrotic effects were evaluated by serum biochemical values, hydroxyproline contents in liver, and light microscopical histology of liver.
In ethanol soluble polysaccharide extracted from Ganoderma lucidum, the result obtained were as follows; Hydroxyproline and PIlIP contents in liver of 5mg/kg treated group were significantly reduced. In serum test ALT AST values were rather increased.
In water soluble polysaccharide extracted from Ganoderma lucidum, the results obtained were as follows; 1) Hydroxyproline contents in liver of 2.0 and 5.0 mg/kg treated group were significantly reduced in dose dependent manner. 2) In serum test, ALT, AST, ALP values in polysaccharide group were lower than BDL/S control group. 3) The hepatic damage such as hepatocellular inflammation, bile duct proliferation and fibrosis was less severe in the livers of 2.0 and 5.0 mg/kg polysaccharide treated rats than BDL/S control groups. These results suggest water soluble polysaccharides from Ganoderma lucidum had the antifibrotic effect on liver cirrhosis induced by BDL/S.