Development of Gelatin Thin Film Reinforced by Modified Gellan Gum and Naringenin-Loaded Zein Nanoparticle as a Wound Dressing

다국어 초록 (Multilingual Abstract)

Today, the importance of biocompatible nanocomposite films with suitable properties for potential applications in wound healing has been considered. In present study, nanocomposite films of gelatin/aldehyde-gellan gum/Naringeninloaded Zein nanoparticle (GL/AG/NR@Z) were successfully produced with the solution casting method. NR@Z with different concentrations (1.5 and 3 wt%) loaded into the GL/AG films. Then, the morphological, structural, thermal, and physical properties of these films were investigated. The obtained findings illustrated that by addition of NR@Z content, a denser and more porous structure with high swelling ratio (around 80%), high thermal stability, high tensile stress (54.33 ± 3.45 MPa), and high weight loss (around 70%) was observed. Cell viability assessment of the produced films displayed no cytotoxicity for NIH3T3 fibroblast cells. Furthermore, since NR is a polyphenolic compound, the produced GL/AG/NR@Z nanocomposite films showed antioxidant and antibacterial activity. Consequently, we demonstrated that nanocomposite films (GL/AG/NR@Z) could be a suitable scaffold for wound healing applications.

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