농촌 기반 코호트 노화 심층조사 사업

국문 초록 (Abstract)

이 연구는 기 구축된 농촌기반 코호트 인프라(6개 지역: 양평, 남원, 고령, 원주, 평창, 강화)를 기반으로
선행 기획과제와 시범사업에서 개발한 코호트 전략과 방법을 적용하여 노화 심층 연구를 위한 인지노
화코호트를 구축하기 위한 2차년도 연구이다. (3년 단위 기반조사 중 2차년도)
? 연구목표 및 연구 내용
목표 1. 농촌기반 코호트 노화 심층연구(인지노화코호트) 2차년도 기반코호트 구축
목표 2. 표준화 프로토콜과 질관리 활동을 적용한 현장조사 수행과 타탕성과 신뢰성 높은 자료생산
2-1. 조사 전 프로토콜 검토와 조사원 교육.훈련
2-2. 인지심리검사, 체력 측정 분야 교육.훈련과 전문가 슈퍼비전
2-3. BDSP 시스템을 통한 뇌영상자료 수집과 관리
2-4. 조사 전 과정에 QC&QA 수행
2-5. 1차년도 자료 크리닝과 데이터 locking ? 연구방법
? 조사대상자
- 5개 연구센터(양평, 남원, 고령, 원주·평창 및 강화)에서 구축된 농촌코호트 대상자 중 코호트에 잔류
하고 있는 만 55세-79세 11,850명 중 2021년 만 55-79세에 해당하며 치매로 진단받지 않은 대상자
930명.
? 5개 코호트 센터에서 현장조사 수행
- 설문조사(과거력, 심리사회특성, 임지심리검사 등), 신체계측(혈압, 체지방, PWV 등)과 체력측정 등
- 인체 시료 수집(Serum, Plasma, Buffy coat, urine)과 검사(일반혈액검사, 일반화학검사, 소변검사)
- 3T Brain MRI 측정
?역학데이터 및 질관리센터, 뇌영상데이터 센터 운영
- 조사 단계별 표준화 교육 및 현장조사를 통한 질관리
- 데이터 수집 및 관리 체계 표준화
- 운영위원회, 자문회의 등을 통해 전 조사 과정과 결과에 대한 질관리 활동 ? 연구결과
1. 농촌기반 코호트 노화 심층연구(인지노화코호트) 기반코호트 구축
- 비교적 짧은 연구기간과 COVID-19 대유행에도 불구하고 2021년 11월 17일 기준 674명 참여자를 모
집하였고(목표 달성도 = 72.5%) 연구기간 내 930명 조사인원(MRI 측정 기준)을 달성할 수 있을 것
으로 판단됨.
- 1차년도에 조사한 911명의 설문과 신체계측 자료 입력 완료와 최종 크리닝 수행 중이며, 2차년도 기
간 중 완료할 예정임
- 1차년도 MRI 측정을 완료한 900명의 BDSP 시스템을 구축하였음.
2. 조사 질관리 활동
? 역학데이터 및 질관리 센터
- 1차년도 연구수행 결과를 바탕으로 현장조사 표준화를 강화할 목적으로, 전체 일관된 기반조사를 유
지하면서 일부 프로토콜과 조사양식을 명확하게 하기 위한 수정작업을 수행하고 기록함.
- 역학정보 데이터 수집 방법, 자료 입력, 관리 체계 표준화 및 질관리 활동
- 표준화 교육, 현장 방문 표준화 교육, 현장 방문 조사 평가와 재교육 수행
- 인지심리검사 질관리: 표준화 교육, 전문가 수퍼비전, RCFT 전문가 판독, 신규 조사원 추가 교육,
K-MMSE 2판 도입과 교육, 인지심리검사 입력시스템 개발
- 6세부과제 뇌영상센터 중심의 뇌MRI: BDSP(Biomedical Data Science Platform) 적용하여 MRI 자료 수
집과 표준화 및 저장, MRI 영상 수집과 검증 그리고 판독을 위한 BDSP 업데이트, 운영과 관리, 영상의
학전문의에 의한 정성적 영상판독(노화에 의한 백질변성, 열공, 미세출혈, 대혈관성 뇌졸중, 뇌엽출혈, 기
타) 제시
? 활용 및 기대효과
○ 기구축된 코호트를 중심으로 한 비용-효과적인 코호트 구축 전략 제시
○ 초 고령사회에서 불가피한 질병부담 증가 완화를 위해 필요한 인지노화 위험요인과 발생 기전을
발굴하고 보건 정책 개발에 활용할 수 있는 기반 자원을 구축

목차 (Table of Contents)

• I. 총괄세부과제 ································································································································ 1
• 제1장 최종 연구목표 ····································································································································· 1
• 제2장 국내외 기술 현황 ···························································································································· 15
• 제3장 최종 연구내용 및 방법 ················································································································ 20
• 제4장 최종 연구결과 ································································································································ 53
• 제5장 연구결과 고찰 및 결론 ·············································································································· 125
• 제6장 연구성과 및 활용계획 ·················································································································· 127
• 제7장 정책연구용역사업 진행과정에서 수집한 해외과학기술정보 ················································ 129
• 제8장 기타 중요변경사항 ························································································································ 129
• 제9장 정책연구용역사업 유사도 검사결과 ·························································································· 129
• 제10장 연구윤리 자가점검표 ·················································································································· 131
• 제11장 연구비 사용 내역 및 연구 분담표 ·························································································· 132
• 제12장 참고문헌 ········································································································································ 136
• 제13장 첨부서류 ········································································································································ 141
• II. 제1세부과제 총괄과 양평코호트 연구센터 ······································································ 142
• 제1장 최종 연구목표 ································································································································ 142
• 제2장 국내외 기술 현황: Ⅰ. 총괄 연구결과 참조 ··········································································· 143
• 제3장 최종 연구내용 및 방법 ················································································································ 144
• 제4장 최종 연구결과 ································································································································ 155
• 제5장 연구결과 고찰 및 결론:Ⅰ. 총괄 연구결과 참조 ··································································· 156
• 제6장 연구성과 및 활용계획 ·················································································································· 157
• 제7장 정책연구용역사업 진행과정에서 수집한 해외과학기술정보 ················································ 159
• 제8장 기타 중요변경사항 ························································································································ 159
• 제9장 정책연구용역사업 유사도 검사결과 ·························································································· 159
• 제10장 연구윤리 자가점검표 ·················································································································· 160
• 제11장 연구비 사용 내역 및 연구 분담표 ·························································································· 161
• 제12장 참고문헌 :Ⅰ. 총괄 연구결과 참조 ························································································· 164
• 제13장 첨부서류:Ⅰ. 총괄 연구결과 참조 ··························································································· 164
• III. 제2세부과제 남원코호트 ····································································································· 165
• 제1장 최종 연구목표 ································································································································ 165
• 제2장 국내외 기술 현황: Ⅰ. 총괄 연구결과 참조 ··········································································· 166
• 제3장 최종 연구내용 및 방법 ················································································································ 166
• 제4장 최종 연구결과 ································································································································ 171
• 제5장 연구결과 고찰 및 결론:Ⅰ. 총괄 연구결과 참조 ··································································· 171
• 제6장 연구성과 및 활용계획 ·················································································································· 172
• 제7장 정책연구용역사업 진행과정에서 수집한 해외과학기술정보 ················································ 174
• 제8장 기타 중요변경사항 ························································································································ 174
• 제9장 정책연구용역사업 유사도 검사결과 ·························································································· 174
• 제10장 연구윤리 자가점검표 ·················································································································· 175
• 제11장 연구비 사용 내역 및 연구 분담표 ·························································································· 176
• 제12장 참고문헌 :Ⅰ. 총괄 연구결과 참조 ························································································· 178
• 제13장 첨부서류:Ⅰ. 총괄 연구결과 참조 ··························································································· 178
• IV. 제3세부과제 고령코호트 ···································································································· 179
• 제1장 최종 연구목표 ································································································································ 179
• 제2장 국내외 기술 현황: Ⅰ. 총괄 연구결과 참조 ··········································································· 180
• 제3장 최종 연구내용 및 방법 ················································································································ 180
• 제4장 최종 연구결과 ································································································································ 184
• 제5장 연구결과 고찰 및 결론:Ⅰ. 총괄 연구결과 참조 ··································································· 185
• 제6장 연구성과 및 활용계획 ·················································································································· 185
• 제7장 정책연구용역사업 진행과정에서 수집한 해외과학기술정보 ················································ 187
• 제8장 기타 중요변경사항 ························································································································ 187
• 제9장 정책연구용역사업 유사도 검사결과 ·························································································· 187
• 제10장 연구윤리 자가점검표 ·················································································································· 189
• 제11장 연구비 사용 내역 및 연구 분담표 ·························································································· 190
• 제12장 참고문헌 :Ⅰ. 총괄 연구결과 참조 ························································································· 192
• 제13장 첨부서류:Ⅰ. 총괄 연구결과 참조 ··························································································· 192
• V. 제4세부과제 원주.평창코호트 ····························································································· 193
• 제1장 최종 연구목표 ································································································································ 193
• 제2장 국내외 기술 현황: Ⅰ. 총괄 연구결과 참조 ··········································································· 194
• 제3장 최종 연구내용 및 방법 ················································································································ 194
• 제4장 최종 연구결과 ································································································································ 203
• 제5장 연구결과 고찰 및 결론:Ⅰ. 총괄 연구결과 참조 ··································································· 203
• 제6장 연구성과 및 활용계획 ·················································································································· 204
• 제7장 정책연구용역사업 진행과정에서 수집한 해외과학기술정보 ················································ 206
• 제8장 기타 중요변경사항 ························································································································ 206
• 제9장 정책연구용역사업 유사도 검사결과 ·························································································· 206
• 제10장 연구윤리 자가점검표 ·················································································································· 208
• 제11장 연구비 사용 내역 및 연구 분담표 ·························································································· 209
• 제12장 참고문헌 :Ⅰ. 총괄 연구결과 참조 ························································································· 211
• 제13장 첨부서류:Ⅰ. 총괄 연구결과 참조 ··························································································· 211
• VI. 제5세부과제 강화코호트 ···································································································· 212
• 제1장 최종 연구목표 ································································································································ 212
• 제2장 국내외 기술 현황: Ⅰ. 총괄 연구결과 참조 ··········································································· 213
• 제3장 최종 연구내용 및 방법 ················································································································ 213
• 제4장 최종 연구결과 ································································································································ 218
• ? Ⅰ. 총괄 연구결과 참조 ·························································································································· 218
• ? Ⅰ. 총괄 연구결과 참조 ·························································································································· 218
• ? Ⅰ. 총괄 연구결과 참조 ·························································································································· 218
• 제5장 연구결과 고찰 및 결론:Ⅰ. 총괄 연구결과 참조 ··································································· 219
• 제6장 연구성과 및 활용계획 ·················································································································· 219
• 제7장 정책연구용역사업 진행과정에서 수집한 해외과학기술정보 ················································ 221
• 제8장 기타 중요변경사항 ························································································································ 221
• 제9장 정책연구용역사업 유사도 검사결과 ·························································································· 221
• 제10장 연구윤리 자가점검표 ·················································································································· 222
• 제11장 연구비 사용 내역 및 연구 분담표 ·························································································· 223
• 제12장 참고문헌 :Ⅰ. 총괄 연구결과 참조 ························································································· 226
• 제13장 첨부서류:Ⅰ. 총괄 연구결과 참조 ··························································································· 226
• VII. 제6세부 뇌영상데이터센터 ······························································································· 227
• 제1장 최종 연구목표 ······························································································································ 227
• 제2장 국내외 기술 현황 ·························································································································· 228
• 제3장 최종 연구내용 및 방법 ················································································································ 230
• 제4장 최종 연구결과 ································································································································ 234
• 제5장 연구결과 고찰 및 결론 ················································································································ 244
• 제6장 연구성과 및 활용계획 ·················································································································· 246
• 제7장 정책연구용역사업 진행과정에서 수집한 해외과학기술정보 ················································ 248
• 제8장 기타 중요변경사항 ························································································································ 248
• 제9장 정책연구용역사업 유사도 검사결과 ·························································································· 249
• 제10장 연구윤리 자가점검표 ·················································································································· 250
• 제11장 연구비 사용 내역 및 연구 분담표 ·························································································· 251
• 제12장 참고문헌 ······································································································································ 253
• 제13장 첨부서류 ······································································································································ 255
• 첨부 서류 ······················································································································································ 256