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      KCI등재 SCI SCIE SCOPUS

      The Protective Effect of Sodium Hyaluronate on the Cartilage of Rabbit Osteoarthritis by Inhibiting Peroxisome Proliferator-Activated Receptor-Gamma Messenger RNA Expression

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      https://www.riss.kr/link?id=A101616769

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      다국어 초록 (Multilingual Abstract)

      Purpose: The purpose of this study was to study the protective effect and influence of sodium hyaluronate (Na-
      HA) on mRNA expression of peroxisome proliferators-activated receptor gamma (PPAR-γ) in cartilage of rabbit
      osteoarthritis (OA) model. Materials and Methods: Forty eight white rabbits were randomly divided into A, B,
      and C groups. Group A was normal control group, B and C groups underwent unilateral anterior cruciate ligament
      transection (ACLT). The rabbits in group B were injected normal saline after ACLT; and Group C received intraarticular1%
      sodium hyaluronate (HA) injection 5 weeks after surgery, 0.3 mL once a week. At 11th week after
      surgery, all the rabbits were sacrificed. The cartilage changes on the medial femoral condyles were graded
      separately. Cartilage sections were stained with safranin-O and HE, and messenger RNA (mRNA) expression of
      PPAR-γ was detected by using real time polymerase chain reaction (Real Time-PCR). Results: Cartilage
      degeneration in group B was significantly more severe than in A and C injection group. The grey value of Safranin-
      O of B group was higher than A and C groups. Expression of PPAR-γ mRNA in group B was higher than group A
      and C. Conclusion: This study shows that Na-HA has a protective effect on articular cartilage degeneration, and
      the inhibitory effect on the PPAR-γ mRNA expression may be one of therapeutic mechanism of Na-HA.
      번역하기

      Purpose: The purpose of this study was to study the protective effect and influence of sodium hyaluronate (Na- HA) on mRNA expression of peroxisome proliferators-activated receptor gamma (PPAR-γ) in cartilage of rabbit osteoarthritis (OA) model. Mate...

      Purpose: The purpose of this study was to study the protective effect and influence of sodium hyaluronate (Na-
      HA) on mRNA expression of peroxisome proliferators-activated receptor gamma (PPAR-γ) in cartilage of rabbit
      osteoarthritis (OA) model. Materials and Methods: Forty eight white rabbits were randomly divided into A, B,
      and C groups. Group A was normal control group, B and C groups underwent unilateral anterior cruciate ligament
      transection (ACLT). The rabbits in group B were injected normal saline after ACLT; and Group C received intraarticular1%
      sodium hyaluronate (HA) injection 5 weeks after surgery, 0.3 mL once a week. At 11th week after
      surgery, all the rabbits were sacrificed. The cartilage changes on the medial femoral condyles were graded
      separately. Cartilage sections were stained with safranin-O and HE, and messenger RNA (mRNA) expression of
      PPAR-γ was detected by using real time polymerase chain reaction (Real Time-PCR). Results: Cartilage
      degeneration in group B was significantly more severe than in A and C injection group. The grey value of Safranin-
      O of B group was higher than A and C groups. Expression of PPAR-γ mRNA in group B was higher than group A
      and C. Conclusion: This study shows that Na-HA has a protective effect on articular cartilage degeneration, and
      the inhibitory effect on the PPAR-γ mRNA expression may be one of therapeutic mechanism of Na-HA.

      더보기

      다국어 초록 (Multilingual Abstract)

      Purpose: The purpose of this study was to study the protective effect and influence of sodium hyaluronate (Na-
      HA) on mRNA expression of peroxisome proliferators-activated receptor gamma (PPAR-γ) in cartilage of rabbit
      osteoarthritis (OA) model. Materials and Methods: Forty eight white rabbits were randomly divided into A, B,
      and C groups. Group A was normal control group, B and C groups underwent unilateral anterior cruciate ligament
      transection (ACLT). The rabbits in group B were injected normal saline after ACLT; and Group C received intraarticular1%
      sodium hyaluronate (HA) injection 5 weeks after surgery, 0.3 mL once a week. At 11th week after
      surgery, all the rabbits were sacrificed. The cartilage changes on the medial femoral condyles were graded
      separately. Cartilage sections were stained with safranin-O and HE, and messenger RNA (mRNA) expression of
      PPAR-γ was detected by using real time polymerase chain reaction (Real Time-PCR). Results: Cartilage
      degeneration in group B was significantly more severe than in A and C injection group. The grey value of Safranin-
      O of B group was higher than A and C groups. Expression of PPAR-γ mRNA in group B was higher than group A
      and C. Conclusion: This study shows that Na-HA has a protective effect on articular cartilage degeneration, and
      the inhibitory effect on the PPAR-γ mRNA expression may be one of therapeutic mechanism of Na-HA.
      번역하기

      Purpose: The purpose of this study was to study the protective effect and influence of sodium hyaluronate (Na- HA) on mRNA expression of peroxisome proliferators-activated receptor gamma (PPAR-γ) in cartilage of rabbit osteoarthritis (OA) model. Ma...

      Purpose: The purpose of this study was to study the protective effect and influence of sodium hyaluronate (Na-
      HA) on mRNA expression of peroxisome proliferators-activated receptor gamma (PPAR-γ) in cartilage of rabbit
      osteoarthritis (OA) model. Materials and Methods: Forty eight white rabbits were randomly divided into A, B,
      and C groups. Group A was normal control group, B and C groups underwent unilateral anterior cruciate ligament
      transection (ACLT). The rabbits in group B were injected normal saline after ACLT; and Group C received intraarticular1%
      sodium hyaluronate (HA) injection 5 weeks after surgery, 0.3 mL once a week. At 11th week after
      surgery, all the rabbits were sacrificed. The cartilage changes on the medial femoral condyles were graded
      separately. Cartilage sections were stained with safranin-O and HE, and messenger RNA (mRNA) expression of
      PPAR-γ was detected by using real time polymerase chain reaction (Real Time-PCR). Results: Cartilage
      degeneration in group B was significantly more severe than in A and C injection group. The grey value of Safranin-
      O of B group was higher than A and C groups. Expression of PPAR-γ mRNA in group B was higher than group A
      and C. Conclusion: This study shows that Na-HA has a protective effect on articular cartilage degeneration, and
      the inhibitory effect on the PPAR-γ mRNA expression may be one of therapeutic mechanism of Na-HA.

      더보기

      참고문헌 (Reference)

      1 Schoonjans K, "The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation" 1302 : 93-109, 1996

      2 Carlberg C, "The orphan receptor family RZR/ ROR, melatonin and 5-lipoxygenase: an unexpected relationship" 18 : 171-178, 1995

      3 Liu SQ, "The effects of carboxymethylated chitosan on metalloproteinase-1, -3 and tissue inhibitor of metalloproteinase-1 gene expression in cartilage of experimental osteoarthritis" 26 : 52-57, 2005

      4 Yasui T, "The effect of hyaluronan on interleukin-1 alpha-induced prostaglandin E2 production in human osteoarthritic synovial cells" 37 : 155-156, 1992

      5 Muir H, "The chondrocyte, architect of cartilage. Biomechanics, structure, function and molecular biology of cartilage matrix macromolecules" 17 : 1039-1048, 1995

      6 Studer R, "Nitric oxide in osteoarthritis" 7 : 377-379, 1999

      7 Hashimoto S, "Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis" 41 : 1632-1638, 1998

      8 Tobetto K, "Inhibitory effects of hyaluronan on [14C]arachidonic acid release from labeled human synovial fibroblasts" 60 : 79-84, 1992

      9 Aizawa T, "Induction of apoptosis in chondrocytes by tumor necrosis factor-alpha" 19 : 785-796, 2001

      10 Miwa M, "Induction of apoptosis in bovine articular chondrocyte by prostaglandin E(2) through cAMP-dependent pathway" 8 : 17-24, 2000

      1 Schoonjans K, "The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation" 1302 : 93-109, 1996

      2 Carlberg C, "The orphan receptor family RZR/ ROR, melatonin and 5-lipoxygenase: an unexpected relationship" 18 : 171-178, 1995

      3 Liu SQ, "The effects of carboxymethylated chitosan on metalloproteinase-1, -3 and tissue inhibitor of metalloproteinase-1 gene expression in cartilage of experimental osteoarthritis" 26 : 52-57, 2005

      4 Yasui T, "The effect of hyaluronan on interleukin-1 alpha-induced prostaglandin E2 production in human osteoarthritic synovial cells" 37 : 155-156, 1992

      5 Muir H, "The chondrocyte, architect of cartilage. Biomechanics, structure, function and molecular biology of cartilage matrix macromolecules" 17 : 1039-1048, 1995

      6 Studer R, "Nitric oxide in osteoarthritis" 7 : 377-379, 1999

      7 Hashimoto S, "Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis" 41 : 1632-1638, 1998

      8 Tobetto K, "Inhibitory effects of hyaluronan on [14C]arachidonic acid release from labeled human synovial fibroblasts" 60 : 79-84, 1992

      9 Aizawa T, "Induction of apoptosis in chondrocytes by tumor necrosis factor-alpha" 19 : 785-796, 2001

      10 Miwa M, "Induction of apoptosis in bovine articular chondrocyte by prostaglandin E(2) through cAMP-dependent pathway" 8 : 17-24, 2000

      11 Sasaki A, "Hyaluronate inhibits the interleukin-1beta-induced expression of matrix metalloproteinase (MMP)-1 and MMP-3 in human synovial cells" 204 : 99-107, 2004

      12 Presti D, "Hyaluronan-mediated protective effect against cell damage caused by enzymatically produced hydroxyl (OH.) radicals is dependent on hyaluronan molecular mass" 12 : 281-288, 1994

      13 Hashimoto S, "Fas/Fas ligand expression and induction of apoptosis in chondrocytes" 40 : 1749-1755, 1997

      14 Shao YY, "Expression and activation of peroxisome proliferator-activated receptors in growth plate chondrocytes" 23 : 1139-1145, 2005

      15 Feng L, "Evidence of a direct role for Bcl-2 in the regulation of articular chondrocyte apoptosis under the conditions of serum withdrawal and retinoic acid treatment" 71 : 302-309, 1998

      16 Bordji K, "Evidence for the presence of peroxisome proliferatoractivated receptor (PPAR) alpha and gamma and retinoid Z receptor in cartilage. PPARgamma activation modulates the effects of interleukin-1beta on rat chondrocytes" 275 : 12243-12250, 2000

      17 Campo GM, "Efficacy of treatment with glycosaminoglycans on experimental collagen-induced arthritis in rats" 5 : R122-R131, 2003

      18 Larsen NE, "Effect of hylan on cartilage and chondrocyte cultures" 10 : 23-32, 1992

      19 Eun Kyung Yoon, "ERK-1/-2 and p38 Kinase Oppositely Regulate 15-deoxy-delta(12,14)-prostaglandinJ2-Induced PPAR-gamma Activation" 대한의학회 22 (22): 1015-1021, 2007

      20 Choy EH, "Cytokine pathways and joint inflammation in rheumatoid arthritis" 344 : 907-916, 2001

      21 Roach HI, "Chondroptosis: a variant of apoptotic cell death in chondrocytes?" 9 : 265-277, 2004

      22 Kühn K, "Cell density modulates apoptosis in human articular chondrocytes" 180 : 439-447, 1999

      23 Shan ZZ, "A Potential role of 15-deoxy (12,14) prostaglandin J2 for induction of human articular chondrocyte apoptosis in arthritis" 279 : 37939-37950, 2004

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2023 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2020-01-01 평가 등재학술지 유지 (해외등재 학술지 평가) KCI등재
      2011-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2009-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2007-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2005-05-31 학술지등록 한글명 : Yonsei Medical Journal
      외국어명 : Yonsei Medical Journal
      KCI등재
      2005-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2002-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2000-01-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 1.42 0.3 0.99
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.83 0.72 0.546 0.08
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