독사조신 복용 후 발생한 여성형유방증 = A Case of Gynecomastia Induced by Use of Doxazosin

다국어 초록 (Multilingual Abstract)

Doxazosin is an adrenergic alpha-1 receptor antagonist used to treat lower urinary tract symptoms that are common in prostatic hyperplasia. To our knowledge, few cases of gynecomastia and mastodynia, as a complication of adrenergic alpha-1 receptor antagonist, have been reported to date; no cases have been reported in Korea. We describe a case involving a 78-year-old man treated for prostatic hyperplasia with 13 months of doxazosin. He complained about unilateral gynecomstia and mastodynia. Five months after the discontinuation of doxazosin, the gynecomastia was significantly improved. This is the first reported case of gynecomastia and mastodynia associated with doxazosin use in Korea. (Korean J Med 2016;90:239-242)

참고문헌 (Reference)

1 Wilton L, "The safety of finasteride used in benign prostatic hypertrophy : a non-interventional observational cohort study in 14, 772 patients" 78 : 379-384, 1996

2 Berry SJ, "The development of human benign prostatic hyperplasia with age" 132 : 474-479, 1984

3 Stojkov NJ, "Orally applied doxazosin disturbed testosterone homeostasis and changed the transcriptional profile of steroidogenic machinery, cAMP/cGMP signalling and adrenergic receptors in Leydig cells of adult rats" 1 : 332-347, 2013

4 Roets E, "Idendification and characterization of 3H-prazosin binding to alpha 1-adrenoceptors in bovine teat muscles" 275 : 189-198, 1985

5 Green L, "Gynecomastia and breast cancer during finasteride therapy" 335 : 823-, 1996

6 Braunstein GD, "Gynecomastia" 328 : 490-495, 1993

7 Dickson G, "Gynecomastia" 85 : 716-722, 2012

8 Bowman JD, "Drug-induced gynecomastia" 32 : 1123-1140, 2012

9 Wellnitz O, "Alpha1c-and beta2-adrenergic receptor mRNA distribution in the bovine mammary gland detected by competitive RT-PCR" 68 : 699-704, 2001

10 Viola E, "Alpha1-adrenergic receptor antagonists and gynecomastia. A case series from the Italian spontaneous reporting system and VigiBaseTM" 70 : 1003-1009, 2014